Summary of mT2* improvements by baseline iron burden in patients treated with DFX-DFO combination followed by DFX monotherapy for 24 months
| Time point . | Baseline LIC, mg Fe/g dw . | Baseline serum ferritin, ng/mL . | ||
|---|---|---|---|---|
| <30 . | ≥30 . | ≤2500 . | >2500 . | |
| Baseline | n = 19 | n = 41 | n = 7 | n = 53 |
| Gmeanbaseline mT2*, (95% CI), ms | 8.04 (7.39, 8.75) | 6.83 (6.43, 7.26) | 7.81 (6.36, 9.60) | 7.12 (6.74, 7.52) |
| Month 24 | n = 15 | n = 21 | n = 6 | n = 30 |
| Gmean24 mT2*, (95% CI), ms | 10.59 (8.90, 12.61) | 8.78 (7.55, 10.23) | 10.49 (7.80, 14.10) | 9.31 (8.18, 10.59) |
| Gmean ratio of month 24/baseline (95% CI) | 1.35 (1.16, 1.58) | 1.26 (1.09, 1.45) | 1.40 (1.07, 1.82) | 1.28 (1.14, 1.43) |
| Time point . | Baseline LIC, mg Fe/g dw . | Baseline serum ferritin, ng/mL . | ||
|---|---|---|---|---|
| <30 . | ≥30 . | ≤2500 . | >2500 . | |
| Baseline | n = 19 | n = 41 | n = 7 | n = 53 |
| Gmeanbaseline mT2*, (95% CI), ms | 8.04 (7.39, 8.75) | 6.83 (6.43, 7.26) | 7.81 (6.36, 9.60) | 7.12 (6.74, 7.52) |
| Month 24 | n = 15 | n = 21 | n = 6 | n = 30 |
| Gmean24 mT2*, (95% CI), ms | 10.59 (8.90, 12.61) | 8.78 (7.55, 10.23) | 10.49 (7.80, 14.10) | 9.31 (8.18, 10.59) |
| Gmean ratio of month 24/baseline (95% CI) | 1.35 (1.16, 1.58) | 1.26 (1.09, 1.45) | 1.40 (1.07, 1.82) | 1.28 (1.14, 1.43) |
CI, confidence interval; DFO, deferoxamine; DFX, deferasirox; dw, dry weight; LIC, liver iron concentration; mT2*, myocardial T2*.