Molecular outcomes from treatment of HSPCs with ZFNs and an oligonucleotide donor
Outcome . | Frequency (%) . |
---|---|
No change | 46.1 |
NHEJ-mediated deletions | 30.5 |
Oligonucleotide-templated gene modification | 18.8 |
NHEJ-mediated insertions | 2.8 |
Half gene modification, half NHEJ | 1.5 |
Capture of the donor oligonucleotide | 0.4 |
Outcome . | Frequency (%) . |
---|---|
No change | 46.1 |
NHEJ-mediated deletions | 30.5 |
Oligonucleotide-templated gene modification | 18.8 |
NHEJ-mediated insertions | 2.8 |
Half gene modification, half NHEJ | 1.5 |
Capture of the donor oligonucleotide | 0.4 |