Risk-stratified outcomes after NMA haplo BMT based on refined DRI
| Variable: refined DRI group . | Probability (95% CI) . | P* . | |||
|---|---|---|---|---|---|
| All patients (n = 372) . | Low risk (n = 71) . | Intermediate risk (n = 241) . | High/very high risk (n = 60) . | ||
| NRM (CuI) | .60 | ||||
| Day 180 | 0.08 (0.05-0.11) | 0.03 (0-0.07) | 0.10 (0.06-0.14) | 0.05 (0-0.11) | |
| 1 y | 0.11 (0.08-0.14) | 0.10 (0.03-0.17) | 0.13 (0.08-0.17) | 0.05 (0-0.11) | |
| Relapse (CuI) | <.0001 | ||||
| 1 y | 0.37 (0.32-0.42) | 0.17 (0.08-0.26) | 0.38 (0.32-0.44) | 0.58 (0.46-0.71) | |
| 3 y | 0.46 (0.41-0.51) | 0.20 (0.11-0.30) | 0.48 (0.41-0.54) | 0.67 (0.55-0.80) | |
| PFS | <.0001 | ||||
| 1 y | 0.52 (0.47-0.57) | 0.73 (0.63-0.84) | 0.50 (0.44-0.56) | 0.37 (0.26-0.51) | |
| 3 y | 0.40 (0.35-0.45) | 0.65 (0.55-0.78) | 0.37 (0.31-0.44) | 0.22 (0.14-0.36) | |
| DFS | <.0001 | ||||
| 1 y | 0.51 (0.46-0.57) | 0.70 (0.60-0.82) | 0.50 (0.44-0.56) | 0.35 (0.25-0.49) | |
| 3 y | 0.61 (0.57-0.66) | 0.64 (0.54-0.76) | 0.37 (0.31-0.44) | 0.22 (0.14-0.36) | |
| OS | .0001 | ||||
| 1 y | 0.68 (0.63-0.73) | 0.81 (0.73-0.91) | 0.67 (0.61-0.73) | 0.55 (0.44-0.69) | |
| 3 y | 0.50 (0.45-0.56) | 0.71 (0.60-0.82) | 0.48 (0.42-0.55) | 0.35 (0.24-0.49) | |
| Variable: refined DRI group . | Probability (95% CI) . | P* . | |||
|---|---|---|---|---|---|
| All patients (n = 372) . | Low risk (n = 71) . | Intermediate risk (n = 241) . | High/very high risk (n = 60) . | ||
| NRM (CuI) | .60 | ||||
| Day 180 | 0.08 (0.05-0.11) | 0.03 (0-0.07) | 0.10 (0.06-0.14) | 0.05 (0-0.11) | |
| 1 y | 0.11 (0.08-0.14) | 0.10 (0.03-0.17) | 0.13 (0.08-0.17) | 0.05 (0-0.11) | |
| Relapse (CuI) | <.0001 | ||||
| 1 y | 0.37 (0.32-0.42) | 0.17 (0.08-0.26) | 0.38 (0.32-0.44) | 0.58 (0.46-0.71) | |
| 3 y | 0.46 (0.41-0.51) | 0.20 (0.11-0.30) | 0.48 (0.41-0.54) | 0.67 (0.55-0.80) | |
| PFS | <.0001 | ||||
| 1 y | 0.52 (0.47-0.57) | 0.73 (0.63-0.84) | 0.50 (0.44-0.56) | 0.37 (0.26-0.51) | |
| 3 y | 0.40 (0.35-0.45) | 0.65 (0.55-0.78) | 0.37 (0.31-0.44) | 0.22 (0.14-0.36) | |
| DFS | <.0001 | ||||
| 1 y | 0.51 (0.46-0.57) | 0.70 (0.60-0.82) | 0.50 (0.44-0.56) | 0.35 (0.25-0.49) | |
| 3 y | 0.61 (0.57-0.66) | 0.64 (0.54-0.76) | 0.37 (0.31-0.44) | 0.22 (0.14-0.36) | |
| OS | .0001 | ||||
| 1 y | 0.68 (0.63-0.73) | 0.81 (0.73-0.91) | 0.67 (0.61-0.73) | 0.55 (0.44-0.69) | |
| 3 y | 0.50 (0.45-0.56) | 0.71 (0.60-0.82) | 0.48 (0.42-0.55) | 0.35 (0.24-0.49) | |
DFS, disease-free survival.
P for differences between refined DRI risk groups, with stratification by BMT year.