Table 2 Preclinical injury models... | American Society of Hematology

Table 2

Preclinical injury models showing beneficial effects of APC variants that have reduced anticoagulant activity or cytoprotective activities

Model	Trigger	End point	APC mutant	APC’s effects	Reference
Sepsis	LPS; bacteria	Death	5A-APC	Reduction	22, 81, 82
Brain I/R	Ischemia	Infarction; swelling; neurologic score	3K3A-APC; 5A-APC	Reduction	6, 15
Cardiac I/R	Ischemia	Coronary damage	APC-2Cys	Reduction	63
ALS	SOD1 mutation	Symptom onset; death	3K3A-APC; 5A-APC	Reduction	24, 83
Traumatic brain injury	Controlled cortical impact	Infarction; angiogenesis; neurogenesis	3K3A-APC	Reduce; promote healing	84
Lung injury	Bacteria	Swelling; vascular leakage; death	5A-APC	Reduction	82
Total body radiation	Lethal radiation	Death	E149A-APC	Reduction	76
Postsurgical adhesion band	Surgery	Adhesion band	APC-2Cys	Reduction	80

Model	Trigger	End point	APC mutant	APC’s effects	Reference
Sepsis	LPS; bacteria	Death	5A-APC	Reduction	22, 81, 82
Brain I/R	Ischemia	Infarction; swelling; neurologic score	3K3A-APC; 5A-APC	Reduction	6, 15
Cardiac I/R	Ischemia	Coronary damage	APC-2Cys	Reduction	63
ALS	SOD1 mutation	Symptom onset; death	3K3A-APC; 5A-APC	Reduction	24, 83
Traumatic brain injury	Controlled cortical impact	Infarction; angiogenesis; neurogenesis	3K3A-APC	Reduce; promote healing	84
Lung injury	Bacteria	Swelling; vascular leakage; death	5A-APC	Reduction	82
Total body radiation	Lethal radiation	Death	E149A-APC	Reduction	76
Postsurgical adhesion band	Surgery	Adhesion band	APC-2Cys	Reduction	80

ALS, amyotrophic lateral sclerosis; LPS, lipopolysaccharide.