Proportional Cox regression analyses of chromosomal changes for PFS and OS among patients displaying del(17p)
| Chromosomal changes . | PFS . | OS . | ||||
|---|---|---|---|---|---|---|
| aHR* . | 95% CI . | P . | aHR . | 95% CI . | P . | |
| Del(13q14) | 1.84 | 1.01-3.34 | .045 | 1.85 | 0.96-3.56 | .064 |
| Del(1p12) | 1.27 | 0.81-1.97 | .300 | 0.87 | 0.53-1.43 | .586 |
| Del(1p32) | 1.36 | 0.78-2.38 | .281 | 1.73 | 0.98-3.05 | .058 |
| t(4;14) | 1.19 | 0.66-2.15 | .562 | 1.20 | 0.63-2.28 | .577 |
| Trisomy 5 | 0.56 | 0.31-1.03 | .064 | 0.43 | 0.21-0.87 | .019 |
| Trisomy 9 | 0.67 | 0.39-1.13 | .134 | 0.52 | 0.28-0.94 | .031 |
| Trisomy 15 | 0.50 | 0.30-0.84 | .009 | 0.53 | 0.30-0.94 | .030 |
| Gain 1q | 2.18 | 1.33-3.58 | .002 | 1.30 | 0.77-2.18 | .325 |
| Del(6q) | 1.75 | 1.08-2.86 | .024 | 1.26 | 0.75-2.11 | .381 |
| Del(8p) | 0.77 | 0.48-1.24 | .285 | 1.14 | 0.69-1.88 | .606 |
| Del(12p) | 1.01 | 0.63-1.60 | .978 | 1.21 | 0.73-1.99 | .456 |
| Monosomy 14 | 0.59 | 0.33-1.07 | .081 | 0.78 | 0.42-1.45 | .429 |
| Del(16q) | 1.08 | 0.68-1.71 | .757 | 1.46 | 0.87-2.45 | .153 |
| Del(22q) | 1.37 | 0.87-2.15 | .169 | 1.52 | 0.93-2.47 | .092 |
| Gain Xq in males | 1.86 | 0.96-3.60 | .067 | 1.18 | 0.60-2.34 | .638 |
| Nullisomy Y | 1.46 | 0.61-3.45 | .394 | 2.57 | 1.03-6.46 | .044 |
| Hyperdiploidy | ||||||
| No | ||||||
| Mild | 0.75 | 0.42-1.36 | .688 | 1.06 | 0.58-1.94 | .843 |
| High | 0.41 | 0.21-0.80 | .009 | 0.43 | 0.20-0.93 | .033 |
| Numerical changes (ref: <4) | ||||||
| 4-8 | 0.91 | 0.52-1.57 | .732 | 0.96 | 0.53-1.76 | .905 |
| ≥8 | 0.43 | 0.24-0.77 | .004 | 0.44 | 0.23-0.84 | .013 |
| Structural changes (ref: <10) | ||||||
| 10-30 | 2.04 | 1.10-3.79 | .024 | 1.33 | 0.68-2.61 | .401 |
| ≥30 | 1.51 | 0.77-2.96 | .228 | 1.28 | 0.62-2.63 | .497 |
| Chromosomal changes . | PFS . | OS . | ||||
|---|---|---|---|---|---|---|
| aHR* . | 95% CI . | P . | aHR . | 95% CI . | P . | |
| Del(13q14) | 1.84 | 1.01-3.34 | .045 | 1.85 | 0.96-3.56 | .064 |
| Del(1p12) | 1.27 | 0.81-1.97 | .300 | 0.87 | 0.53-1.43 | .586 |
| Del(1p32) | 1.36 | 0.78-2.38 | .281 | 1.73 | 0.98-3.05 | .058 |
| t(4;14) | 1.19 | 0.66-2.15 | .562 | 1.20 | 0.63-2.28 | .577 |
| Trisomy 5 | 0.56 | 0.31-1.03 | .064 | 0.43 | 0.21-0.87 | .019 |
| Trisomy 9 | 0.67 | 0.39-1.13 | .134 | 0.52 | 0.28-0.94 | .031 |
| Trisomy 15 | 0.50 | 0.30-0.84 | .009 | 0.53 | 0.30-0.94 | .030 |
| Gain 1q | 2.18 | 1.33-3.58 | .002 | 1.30 | 0.77-2.18 | .325 |
| Del(6q) | 1.75 | 1.08-2.86 | .024 | 1.26 | 0.75-2.11 | .381 |
| Del(8p) | 0.77 | 0.48-1.24 | .285 | 1.14 | 0.69-1.88 | .606 |
| Del(12p) | 1.01 | 0.63-1.60 | .978 | 1.21 | 0.73-1.99 | .456 |
| Monosomy 14 | 0.59 | 0.33-1.07 | .081 | 0.78 | 0.42-1.45 | .429 |
| Del(16q) | 1.08 | 0.68-1.71 | .757 | 1.46 | 0.87-2.45 | .153 |
| Del(22q) | 1.37 | 0.87-2.15 | .169 | 1.52 | 0.93-2.47 | .092 |
| Gain Xq in males | 1.86 | 0.96-3.60 | .067 | 1.18 | 0.60-2.34 | .638 |
| Nullisomy Y | 1.46 | 0.61-3.45 | .394 | 2.57 | 1.03-6.46 | .044 |
| Hyperdiploidy | ||||||
| No | ||||||
| Mild | 0.75 | 0.42-1.36 | .688 | 1.06 | 0.58-1.94 | .843 |
| High | 0.41 | 0.21-0.80 | .009 | 0.43 | 0.20-0.93 | .033 |
| Numerical changes (ref: <4) | ||||||
| 4-8 | 0.91 | 0.52-1.57 | .732 | 0.96 | 0.53-1.76 | .905 |
| ≥8 | 0.43 | 0.24-0.77 | .004 | 0.44 | 0.23-0.84 | .013 |
| Structural changes (ref: <10) | ||||||
| 10-30 | 2.04 | 1.10-3.79 | .024 | 1.33 | 0.68-2.61 | .401 |
| ≥30 | 1.51 | 0.77-2.96 | .228 | 1.28 | 0.62-2.63 | .497 |
HR adjusted for age, treatment type, and β2m level.