Frequency of the most important chromosomal abnormalities in the t(4;14) only (n = 132), del(17p) only (n = 85), and high-risk (n = 25) subgroups
| Chromosomal changes . | t(4;14) alone, n = 132 . | Del(17p) alone, n = 85 . | t(4;14) and del(17p) positive, n=25 . |
|---|---|---|---|
| Hyperdiploidy | |||
| No | 66.7 | 60.6 | 92.0 |
| Mild | 20.4 | 21.1 | 0.0 |
| Large | 12.9 | 18.3 | 8.0 |
| Number of chromosomes (median IQR) | 45 (44-48) | 45 (43-50) | 45 (43-45) |
| Structural chromosomal changes | 46.2 | 28.2 | 4.0 |
| <10 | |||
| 10-30 | 49.2 | 42.2 | 56.0 |
| ≥30 | 4.6 | 29.6 | 40.0 |
| Structural chromosomal changes (median IQR) | 10 (6-17) | 16 (9-34) | 23 (15-41) |
| Del(13q14) | 81.1 | 74.7 | 92.0 |
| Del(1p12) | 37.1 | 52.1 | 56.0 |
| Del(1p32) | 6.8 | 29.6 | 24.0 |
| Chromosome 1q gain | 68.9 | 31.0 | 56.0 |
| Chromosome 6p gain | 18.9 | 18.3 | 8.0 |
| Del(6q) | 24.2 | 42.3 | 56.0 |
| Del(8p) | 25.0 | 45.1 | 36.0 |
| Del(12p) | 34.9 | 31.0 | 40.0 |
| Del(14q) | 47.7 | 46.5 | 68.0 |
| Monosomy 14 | 17.4 | 19.7 | 24.0 |
| Del(16q) | 8.3 | 53.5 | 24.0 |
| Del(22q) | 47.7 | 43.7 | 48.0 |
| Nullisomy Y | 24.7 | 24.3 | 21.4 |
| Chromosomal changes . | t(4;14) alone, n = 132 . | Del(17p) alone, n = 85 . | t(4;14) and del(17p) positive, n=25 . |
|---|---|---|---|
| Hyperdiploidy | |||
| No | 66.7 | 60.6 | 92.0 |
| Mild | 20.4 | 21.1 | 0.0 |
| Large | 12.9 | 18.3 | 8.0 |
| Number of chromosomes (median IQR) | 45 (44-48) | 45 (43-50) | 45 (43-45) |
| Structural chromosomal changes | 46.2 | 28.2 | 4.0 |
| <10 | |||
| 10-30 | 49.2 | 42.2 | 56.0 |
| ≥30 | 4.6 | 29.6 | 40.0 |
| Structural chromosomal changes (median IQR) | 10 (6-17) | 16 (9-34) | 23 (15-41) |
| Del(13q14) | 81.1 | 74.7 | 92.0 |
| Del(1p12) | 37.1 | 52.1 | 56.0 |
| Del(1p32) | 6.8 | 29.6 | 24.0 |
| Chromosome 1q gain | 68.9 | 31.0 | 56.0 |
| Chromosome 6p gain | 18.9 | 18.3 | 8.0 |
| Del(6q) | 24.2 | 42.3 | 56.0 |
| Del(8p) | 25.0 | 45.1 | 36.0 |
| Del(12p) | 34.9 | 31.0 | 40.0 |
| Del(14q) | 47.7 | 46.5 | 68.0 |
| Monosomy 14 | 17.4 | 19.7 | 24.0 |
| Del(16q) | 8.3 | 53.5 | 24.0 |
| Del(22q) | 47.7 | 43.7 | 48.0 |
| Nullisomy Y | 24.7 | 24.3 | 21.4 |
IQR, interquartile range.