Distal tibia and radius bone parameters and biomechanical bone strength (derived from μFEA of HR-pQCT images)
| . | Tibia . | Radius . | ||||
|---|---|---|---|---|---|---|
| Hemophilia . | Control . | P value . | Hemophilia . | Control . | P value . | |
| HR-pQCT bone parameters | ||||||
| BMD, mg HA/cm3 | 288.9 ± 15.8 | 346.7 ± 7.3 | .003 | 313 ± 19.8 | 372.3 ± 8.9 | .012 |
| Trabecular parameters | ||||||
| BV/TV | 0.15 ± 0.008 | 0.18 ± 0.005 | .004 | 0.14 ± 0.01 | 0.17 ± 0.005 | .014 |
| Tb.N, 1/mm | 1.7 ± 0.05 | 2.0 ± 0.05 | <.001 | 1.9 ± 0.07 | 2.0 ± 0.04 | NS |
| Tb.Th, mm | 0.1 ± 0.005 | 0.09 ± 0.002 | NS | 0.07 ± 0.005 | 0.08 ± 0.002 | NS |
| Tb.Sp, mm | 0.52 ± 0.02 | 0.42 ± 0.01 | <.001 | 0.46 ± 0.02 | 0.41 ± 0.01 | .045 |
| Cortical parameters | ||||||
| Ct.BMD, mg HA/cm3 | 880 ± 19.9 | 928 ± 5.4 | .032 | 916 ± 10.9 | 958 ± 6.9 | .003 |
| Ct.Th, mm | 1.3 ± 0.07 | 1.5 ± 0.04 | .049 | 0.93 ± 0.06 | 1.1 ± 0.03 | .016 |
| Ct.Po, % | 5.9 ± 0.87 | 4.9 ± 0.27 | NS | 2.0 ± 0.15 | 1.9 ± 0.14 | NS |
| Biomechanical bone strength (derived from μFEA) | ||||||
| Estimated failure load, N | 6357 ± 377 | 7573 ± 217 | .009 | 2371 ± 162 | 3013 ± 90 | .002 |
| . | Tibia . | Radius . | ||||
|---|---|---|---|---|---|---|
| Hemophilia . | Control . | P value . | Hemophilia . | Control . | P value . | |
| HR-pQCT bone parameters | ||||||
| BMD, mg HA/cm3 | 288.9 ± 15.8 | 346.7 ± 7.3 | .003 | 313 ± 19.8 | 372.3 ± 8.9 | .012 |
| Trabecular parameters | ||||||
| BV/TV | 0.15 ± 0.008 | 0.18 ± 0.005 | .004 | 0.14 ± 0.01 | 0.17 ± 0.005 | .014 |
| Tb.N, 1/mm | 1.7 ± 0.05 | 2.0 ± 0.05 | <.001 | 1.9 ± 0.07 | 2.0 ± 0.04 | NS |
| Tb.Th, mm | 0.1 ± 0.005 | 0.09 ± 0.002 | NS | 0.07 ± 0.005 | 0.08 ± 0.002 | NS |
| Tb.Sp, mm | 0.52 ± 0.02 | 0.42 ± 0.01 | <.001 | 0.46 ± 0.02 | 0.41 ± 0.01 | .045 |
| Cortical parameters | ||||||
| Ct.BMD, mg HA/cm3 | 880 ± 19.9 | 928 ± 5.4 | .032 | 916 ± 10.9 | 958 ± 6.9 | .003 |
| Ct.Th, mm | 1.3 ± 0.07 | 1.5 ± 0.04 | .049 | 0.93 ± 0.06 | 1.1 ± 0.03 | .016 |
| Ct.Po, % | 5.9 ± 0.87 | 4.9 ± 0.27 | NS | 2.0 ± 0.15 | 1.9 ± 0.14 | NS |
| Biomechanical bone strength (derived from μFEA) | ||||||
| Estimated failure load, N | 6357 ± 377 | 7573 ± 217 | .009 | 2371 ± 162 | 3013 ± 90 | .002 |
Unless otherwise specified, values are presented as percentage or mean ± SE. Comparisons of bone parameters are adjusted for age and sex.
BMD, total volumetric bone mineral density; BV/TV, trabecular bone volume to total volume ratio (a measure of trabecular bone mineral density); Ct.BMD, cortical bone mineral density; Ct.Po, cortical porosity; Ct.Th, cortical thickness; HA, hydroxyapatite; N, newton; Tb.N, trabecular number; Tb.Sp, trabecular separation; Tb.Th, trabecular thickness; μFEA, microfinite element analysis.