Multivariate Cox regression analysis
| Parameter . | P value . | HR . | 95% HR . | |
|---|---|---|---|---|
| Confidence limits . | ||||
| 5hmC: <0.023 vs 0.023 to <0.070 | .44 | 1.18 | 0.77 | 1.81 |
| 5hmC: ≥0.070 vs 0.023 to <0.070 | .01 | 2.10 | 1.16 | 3.80 |
| Cytogenetics/FLT3-ITD: good vs intermediate | .21 | 0.60 | 0.25 | 1.36 |
| Cytogenetics/FLT3-ITD: others vs intermediate | .17 | 1.44 | 0.86 | 2.39 |
| Cytogenetics/FLT3-ITD: poor vs intermediate | <.0001 | 3.00 | 1.90 | 4.68 |
| Cytogenetics/FLT3-ITD: unknown vs intermediate | .02 | 2.96 | 1.21 | 7.21 |
| Parameter . | P value . | HR . | 95% HR . | |
|---|---|---|---|---|
| Confidence limits . | ||||
| 5hmC: <0.023 vs 0.023 to <0.070 | .44 | 1.18 | 0.77 | 1.81 |
| 5hmC: ≥0.070 vs 0.023 to <0.070 | .01 | 2.10 | 1.16 | 3.80 |
| Cytogenetics/FLT3-ITD: good vs intermediate | .21 | 0.60 | 0.25 | 1.36 |
| Cytogenetics/FLT3-ITD: others vs intermediate | .17 | 1.44 | 0.86 | 2.39 |
| Cytogenetics/FLT3-ITD: poor vs intermediate | <.0001 | 3.00 | 1.90 | 4.68 |
| Cytogenetics/FLT3-ITD: unknown vs intermediate | .02 | 2.96 | 1.21 | 7.21 |
Akaike information criterion for this model = 1238.
Addition of age, treatment arm (data not shown), and/or percentage BM blasts (supplemental Table 12) in the model did not improve its prognostic discrimination value. Considering 5hmC as a continuous variable in the model (linear and quadratic effect), and adjusting for cytogenetic/FLT3-ITD risk groups, provided similar results as the model indicated above (supplemental Table 12).