VWF variants with decreased collagen 4 binding
| VWF variant . | VWF types . | VWF:RCo/VWF:Ag ratio (range) . | VWF:CB4/VWF:Ag ratio (range) . | Bleeding score (range) . |
|---|---|---|---|---|
| p.R1399H | Healthy controls type 1 VWD | 0.93-1.13 | 0-0.31 | 0-8 |
| p.R1315C | Type 1 | 0.82-1.17 | 0-0.59 | 2-12 |
| p.S1358N | Type 2M | 0.54 | 0.4 | 12 |
| p.Q1402P | Type 2M | 0.38 | 0 | 14 |
| p.R1392_Q1402del | Type 2M | 0.41 | 0 | 11 |
| p.I1425F and p.R1399H | Type 2M | 0.34 | 0.48 | 22 |
| VWF variant . | VWF types . | VWF:RCo/VWF:Ag ratio (range) . | VWF:CB4/VWF:Ag ratio (range) . | Bleeding score (range) . |
|---|---|---|---|---|
| p.R1399H | Healthy controls type 1 VWD | 0.93-1.13 | 0-0.31 | 0-8 |
| p.R1315C | Type 1 | 0.82-1.17 | 0-0.59 | 2-12 |
| p.S1358N | Type 2M | 0.54 | 0.4 | 12 |
| p.Q1402P | Type 2M | 0.38 | 0 | 14 |
| p.R1392_Q1402del | Type 2M | 0.41 | 0 | 11 |
| p.I1425F and p.R1399H | Type 2M | 0.34 | 0.48 | 22 |