Additive total score and related rate of OS and PFS at 3 years
| Additive total score . | Patient status . | No. of patients (%) . | % (95% CI) . | Cumulative incidence at 12 mo, % . | ||
|---|---|---|---|---|---|---|
| OS . | PFS . | Treatment discontinuation . | Grade 3-4 nonhematologic AEs . | |||
| 0 | Fit | 340 (39) | 84 (78-89) | 48 (41-56) | 16 | 22 |
| 1 | Intermediate-fitness | 269 (31) | 76 (67-82) | 41 (32-49) | 21 | 26 |
| ≥2 | Frail | 260 (30) | 57 (45-68) | 33 (25-41) | 31 | 34 |
| Additive total score . | Patient status . | No. of patients (%) . | % (95% CI) . | Cumulative incidence at 12 mo, % . | ||
|---|---|---|---|---|---|---|
| OS . | PFS . | Treatment discontinuation . | Grade 3-4 nonhematologic AEs . | |||
| 0 | Fit | 340 (39) | 84 (78-89) | 48 (41-56) | 16 | 22 |
| 1 | Intermediate-fitness | 269 (31) | 76 (67-82) | 41 (32-49) | 21 | 26 |
| ≥2 | Frail | 260 (30) | 57 (45-68) | 33 (25-41) | 31 | 34 |
In the univariate Cox model, the Harrell C index = 0.6608 and the AIC = 1766.077. In the multivariate Cox model, the Harrell C index = 0.7092 and the AIC = 1743.353.