Gene ontology analysis of transcripts deregulated in untreated and poly(I:C) treated Cdk6−/− fraction A cells
| GO ID . | Description . | Representative genes upregulated . | Representative genes downregulated . |
|---|---|---|---|
| Untreated | |||
| GO:0070887 | Cellular response to chemical stimulus | Arnt, Cntf, Egr1, Ern1, Esr1, Etv5, Kif16b, Nr4a2, Rabgef1, Skil, Smad7 | Aicda, Bcar1, Bmp2, Ccl6, Cxcr2, Lyst, Ngfr, Pax2, Tbx1, Timp2, Trib1 |
| GO:0098552 | Side of membrane | Amot, Cxcl9, Dlk1, Folr2,Hyal2, Il12rb1, Klre1 | Cd74, Cd80, Ceacam2, Efna5, Fas, Fcer1a, Itga1, Rasa2 |
| GO:0009605 | Response to external stimulus | Bmp7, Chn1, Gbp6, Nr4a2, Rab38 | Ablim1, Cxcr1, L1cam, Ngfr, Penk, Slit3 |
| GO:0031012 | Extracellular matrix | Chad, Col16a1, Col18a1, Dspp, Prss12 | Ache, Gpc3, Leprel1, Lox, Lpl, Otog, Serac1, Vcan |
| GO:0048583 | Regulation of response to stimulus | Amot, Egr1, Klre1, Rabgef1, Sybu | Acp5, Apod, Disc1, Fcgr3, Notch1, Slit3 |
| GO:0009986 | Cell surface | Cxcl9, Dlk1, Folr2, H2-K1, Klre1 | Ache, Ceacam2, Clec7a, Efna5, Gfra1, Ramp1 |
| GO:0043235 | Receptor complex | Il12rb1, Rnmt | Cacng3, Card11, Egfr, Gpr160, Itga1 |
| GO:0031224 | Intrinsic component of membrane | Apool, B4galt7, Gpr125, Plscr4, Zdhhc20 | Ache, Clcc1, Grina, Layn, Scn11a, Tmem160 |
| GO:0032502 | Developmental process | Catsper4, Dpf1, Nanog, Rbm19, Tshz1 | Antxr1, Cdh4, Dkkl1, E2f7, Elk1, Tg |
| GO:0005615 | Extracellular space | C1rl, Cntf, Eef1a1, Fam20c, Retn | Acta2, Cfb, Ctsk, Inhba, Lepr |
| GO:0040011 | Locomotion | Bmp7, Hyal2, Nr4a1, P2ry1 | Ablim1, Cemip, Dock4, L1cam, Snai2 |
| Poly:IC treated | |||
| GO:0070887 | Cellular response to chemical stimulus | Ahr, Ctr9, Dgat2, Egr1, Egr2, Egr3, Klf4, Nfil3 | Ackr4, Fam132a, Gcg, Phip, Pklr |
| GO:0001071 | Nucleic acid binding transcription factor activity | Btg2, Fosl2, Hes1, Id3, Mafb | E2f7, Foxl2, Hmga1, Nkx2-2, Zfp628 |
| GO:0016265 | Death | Adamtsl4, Hcar2, Lgmn, Perp, Xaf1 | Atm, Gcg, Optn, Phip, Wrn |
| GO:0010033 | Response to organic substance | Dgat2, Egr1, Egr2, Egr3, Fosl2, Mgst1 | Fgf8, Gpd1, Hpx, Iigp1, Pklr |
| GO:0003677 | DNA binding | Csrnp1, Hes1, Hist1h1c, Nfil3, Tbx3 | E2f7, Jrk, Sox6, Zfp518a, Zfp628 |
| GO ID . | Description . | Representative genes upregulated . | Representative genes downregulated . |
|---|---|---|---|
| Untreated | |||
| GO:0070887 | Cellular response to chemical stimulus | Arnt, Cntf, Egr1, Ern1, Esr1, Etv5, Kif16b, Nr4a2, Rabgef1, Skil, Smad7 | Aicda, Bcar1, Bmp2, Ccl6, Cxcr2, Lyst, Ngfr, Pax2, Tbx1, Timp2, Trib1 |
| GO:0098552 | Side of membrane | Amot, Cxcl9, Dlk1, Folr2,Hyal2, Il12rb1, Klre1 | Cd74, Cd80, Ceacam2, Efna5, Fas, Fcer1a, Itga1, Rasa2 |
| GO:0009605 | Response to external stimulus | Bmp7, Chn1, Gbp6, Nr4a2, Rab38 | Ablim1, Cxcr1, L1cam, Ngfr, Penk, Slit3 |
| GO:0031012 | Extracellular matrix | Chad, Col16a1, Col18a1, Dspp, Prss12 | Ache, Gpc3, Leprel1, Lox, Lpl, Otog, Serac1, Vcan |
| GO:0048583 | Regulation of response to stimulus | Amot, Egr1, Klre1, Rabgef1, Sybu | Acp5, Apod, Disc1, Fcgr3, Notch1, Slit3 |
| GO:0009986 | Cell surface | Cxcl9, Dlk1, Folr2, H2-K1, Klre1 | Ache, Ceacam2, Clec7a, Efna5, Gfra1, Ramp1 |
| GO:0043235 | Receptor complex | Il12rb1, Rnmt | Cacng3, Card11, Egfr, Gpr160, Itga1 |
| GO:0031224 | Intrinsic component of membrane | Apool, B4galt7, Gpr125, Plscr4, Zdhhc20 | Ache, Clcc1, Grina, Layn, Scn11a, Tmem160 |
| GO:0032502 | Developmental process | Catsper4, Dpf1, Nanog, Rbm19, Tshz1 | Antxr1, Cdh4, Dkkl1, E2f7, Elk1, Tg |
| GO:0005615 | Extracellular space | C1rl, Cntf, Eef1a1, Fam20c, Retn | Acta2, Cfb, Ctsk, Inhba, Lepr |
| GO:0040011 | Locomotion | Bmp7, Hyal2, Nr4a1, P2ry1 | Ablim1, Cemip, Dock4, L1cam, Snai2 |
| Poly:IC treated | |||
| GO:0070887 | Cellular response to chemical stimulus | Ahr, Ctr9, Dgat2, Egr1, Egr2, Egr3, Klf4, Nfil3 | Ackr4, Fam132a, Gcg, Phip, Pklr |
| GO:0001071 | Nucleic acid binding transcription factor activity | Btg2, Fosl2, Hes1, Id3, Mafb | E2f7, Foxl2, Hmga1, Nkx2-2, Zfp628 |
| GO:0016265 | Death | Adamtsl4, Hcar2, Lgmn, Perp, Xaf1 | Atm, Gcg, Optn, Phip, Wrn |
| GO:0010033 | Response to organic substance | Dgat2, Egr1, Egr2, Egr3, Fosl2, Mgst1 | Fgf8, Gpd1, Hpx, Iigp1, Pklr |
| GO:0003677 | DNA binding | Csrnp1, Hes1, Hist1h1c, Nfil3, Tbx3 | E2f7, Jrk, Sox6, Zfp518a, Zfp628 |
Most significantly deregulated functional pathways and their Gene Ontology (GO) codes are shown first.