Table 1 Laboratory patterns of different... | American Society of Hematology

Table 1

Laboratory patterns of different types of VWD

	VWF:Ag	VWF:RCo	VWF:RCo/VWF:Ag	FVIII:C	Multimer pattern	Platelet count	Specialized testing
Quantitative disorders of VWF
Type 1	↓	↓	≥0.6	Normal to ↓	Normal	Normal
Type 1C	↓	↓	≥0.6	Normal to ↓	Normal	Normal	Increased VWFpp/VWF:Ag ratio
Low VWF levels	↓	↓	≥0.6	Normal to ↓	Normal	Normal
Type 3	↓↓↓	↓↓↓	≥0.6	↓↓↓	Absent	Normal
Qualitative disorders of VWF
Type 2A	↓	↓↓	≤0.6	Normal to ↓	Loss of HMW-VWF	Normal
Type 2B	↓	↓↓	≤0.6	Normal to ↓	Loss of HMW-VWF	↓↓	LD-RIPA enhanced with patient-derived plasma (VWF)
Platelet-type VWD	↓	↓↓	≤0.6	Normal	Loss of HMW-VWF	↓↓	LD-RIPA enhanced with patient-derived platelets
Type 2M	↓	↓↓	≤0.6	Normal to ↓	Normal	Normal
Type 2N	Normal to ↓	Normal to ↓	≥0.6	↓↓	Normal	Normal	Decreased VWF:FVIII-binding capacity

	VWF:Ag	VWF:RCo	VWF:RCo/VWF:Ag	FVIII:C	Multimer pattern	Platelet count	Specialized testing
Quantitative disorders of VWF
Type 1	↓	↓	≥0.6	Normal to ↓	Normal	Normal
Type 1C	↓	↓	≥0.6	Normal to ↓	Normal	Normal	Increased VWFpp/VWF:Ag ratio
Low VWF levels	↓	↓	≥0.6	Normal to ↓	Normal	Normal
Type 3	↓↓↓	↓↓↓	≥0.6	↓↓↓	Absent	Normal
Qualitative disorders of VWF
Type 2A	↓	↓↓	≤0.6	Normal to ↓	Loss of HMW-VWF	Normal
Type 2B	↓	↓↓	≤0.6	Normal to ↓	Loss of HMW-VWF	↓↓	LD-RIPA enhanced with patient-derived plasma (VWF)
Platelet-type VWD	↓	↓↓	≤0.6	Normal	Loss of HMW-VWF	↓↓	LD-RIPA enhanced with patient-derived platelets
Type 2M	↓	↓↓	≤0.6	Normal to ↓	Normal	Normal
Type 2N	Normal to ↓	Normal to ↓	≥0.6	↓↓	Normal	Normal	Decreased VWF:FVIII-binding capacity

HMW, high molecular weight. ↓, mild decrease; ↓↓, moderate decrease; ↓↓↓, severe decrease.