3D telomere characteristics in RS-like cells without LMP1 (BJAB-tTA-LMP1 with tetracycline; n = 104) and with LMP1 (BJAB-tTA-LMP1 without tetracycline; n = 96)
| Analysis/parameter for pool of days 7, 10, and 21 . | LMP1 suppressed . | LMP1 induced . | P . |
|---|---|---|---|
| Total nuclear volume (μm3) | 2958 ± 1891 | 5375 ± 3572 | <.0001 |
| No. of telomeres per cell | 98.9 ± 41.7 | 149.1 ± 71.6 | <.0001 |
| No. of telomeres per 1000 μm3 of nuclear volume | 38.1 ± 14.3 | 32.2 ± 16.4 | .0070 |
| % of short telomeres (<15 000 units) | 76.9 | 77.1 | >.05* |
| No. of telomere aggregates per cell | 11.8 ± 6.1 | 18.0 ± 10.1 | <.0001 |
| % of cells with ≥20 aggregates | 9.9 | 38.5 | <.0001 |
| Analysis/parameter for pool of days 7, 10, and 21 . | LMP1 suppressed . | LMP1 induced . | P . |
|---|---|---|---|
| Total nuclear volume (μm3) | 2958 ± 1891 | 5375 ± 3572 | <.0001 |
| No. of telomeres per cell | 98.9 ± 41.7 | 149.1 ± 71.6 | <.0001 |
| No. of telomeres per 1000 μm3 of nuclear volume | 38.1 ± 14.3 | 32.2 ± 16.4 | .0070 |
| % of short telomeres (<15 000 units) | 76.9 | 77.1 | >.05* |
| No. of telomere aggregates per cell | 11.8 ± 6.1 | 18.0 ± 10.1 | <.0001 |
| % of cells with ≥20 aggregates | 9.9 | 38.5 | <.0001 |
Values are means ± standard deviation unless otherwise noted.
Not significant.