Table 1 Multivariate Cox model results,... | American Society of Hematology

Table 1

Multivariate Cox model results, including response

Variable	PFS				OS
	Univariate		Multivariate		Univariate		Multivariate
	χ²	P value	χ²	P value	χ²	P value	χ²	P value
Log (MRD)	33.0	<.0001	19.4	<.0001	12.4	.0004	11.8	.0006
Response after ASCT*	20.5	<.0001	1.3	.25	6.60	.01	0.00	.99
International Staging System (1-3)	4.5	.03	0.72	.40	12.9	.0003	1.9	.16
Cytogenetics†	39.8	<.0001	41.3	<.0001	36.9	<.0001	35.5	<.0001
Log (B2M)	8.3	.004	1.8	.18	11.9	.0006	0.34	.56
Platelets‡	10.6	.001	3.8	.05	2.1	.14	0.00	.98
Hemoglobin¶	15.0	.0001	7.5	.006	8.5	.003	1.7	.19
Age (continuous)	0.1	.75	0.01	.92	1.7	.20	1.9	.17
Sex	0.3	.58	0.23	.63	0.01	.93	0.04	.85

Variable	PFS				OS
	Univariate		Multivariate		Univariate		Multivariate
	χ²	P value	χ²	P value	χ²	P value	χ²	P value
Log (MRD)	33.0	<.0001	19.4	<.0001	12.4	.0004	11.8	.0006
Response after ASCT*	20.5	<.0001	1.3	.25	6.60	.01	0.00	.99
International Staging System (1-3)	4.5	.03	0.72	.40	12.9	.0003	1.9	.16
Cytogenetics†	39.8	<.0001	41.3	<.0001	36.9	<.0001	35.5	<.0001
Log (B2M)	8.3	.004	1.8	.18	11.9	.0006	0.34	.56
Platelets‡	10.6	.001	3.8	.05	2.1	.14	0.00	.98
Hemoglobin¶	15.0	.0001	7.5	.006	8.5	.003	1.7	.19
Age (continuous)	0.1	.75	0.01	.92	1.7	.20	1.9	.17
Sex	0.3	.58	0.23	.63	0.01	.93	0.04	.85

Univariate and multivariate analysis demonstrating that the level of MRD at day 100 after ASCT, assessed by multiparameter flow cytometry, is an independent predictor of both PFS and OS. Shaded cells indicate significant variables (P < .05).

CRs vs rest.

†

Favorable vs unfavorable vs unknown/inevaluable.

‡

Stratification factor: <11.5 vs ≥11.5.

Stratification factor: <150 vs ≥150.

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