Multivariate Cox model results, including response
| Variable . | PFS . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate . | Multivariate . | Univariate . | Multivariate . | |||||
| χ2 . | P value . | χ2 . | P value . | χ2 . | P value . | χ2 . | P value . | |
| Log (MRD) | 33.0 | <.0001 | 19.4 | <.0001 | 12.4 | .0004 | 11.8 | .0006 |
| Response after ASCT* | 20.5 | <.0001 | 1.3 | .25 | 6.60 | .01 | 0.00 | .99 |
| International Staging System (1-3) | 4.5 | .03 | 0.72 | .40 | 12.9 | .0003 | 1.9 | .16 |
| Cytogenetics† | 39.8 | <.0001 | 41.3 | <.0001 | 36.9 | <.0001 | 35.5 | <.0001 |
| Log (B2M) | 8.3 | .004 | 1.8 | .18 | 11.9 | .0006 | 0.34 | .56 |
| Platelets‡ | 10.6 | .001 | 3.8 | .05 | 2.1 | .14 | 0.00 | .98 |
| Hemoglobin¶ | 15.0 | .0001 | 7.5 | .006 | 8.5 | .003 | 1.7 | .19 |
| Age (continuous) | 0.1 | .75 | 0.01 | .92 | 1.7 | .20 | 1.9 | .17 |
| Sex | 0.3 | .58 | 0.23 | .63 | 0.01 | .93 | 0.04 | .85 |
| Variable . | PFS . | OS . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariate . | Multivariate . | Univariate . | Multivariate . | |||||
| χ2 . | P value . | χ2 . | P value . | χ2 . | P value . | χ2 . | P value . | |
| Log (MRD) | 33.0 | <.0001 | 19.4 | <.0001 | 12.4 | .0004 | 11.8 | .0006 |
| Response after ASCT* | 20.5 | <.0001 | 1.3 | .25 | 6.60 | .01 | 0.00 | .99 |
| International Staging System (1-3) | 4.5 | .03 | 0.72 | .40 | 12.9 | .0003 | 1.9 | .16 |
| Cytogenetics† | 39.8 | <.0001 | 41.3 | <.0001 | 36.9 | <.0001 | 35.5 | <.0001 |
| Log (B2M) | 8.3 | .004 | 1.8 | .18 | 11.9 | .0006 | 0.34 | .56 |
| Platelets‡ | 10.6 | .001 | 3.8 | .05 | 2.1 | .14 | 0.00 | .98 |
| Hemoglobin¶ | 15.0 | .0001 | 7.5 | .006 | 8.5 | .003 | 1.7 | .19 |
| Age (continuous) | 0.1 | .75 | 0.01 | .92 | 1.7 | .20 | 1.9 | .17 |
| Sex | 0.3 | .58 | 0.23 | .63 | 0.01 | .93 | 0.04 | .85 |
Univariate and multivariate analysis demonstrating that the level of MRD at day 100 after ASCT, assessed by multiparameter flow cytometry, is an independent predictor of both PFS and OS. Shaded cells indicate significant variables (P < .05).
CRs vs rest.
Favorable vs unfavorable vs unknown/inevaluable.
Stratification factor: <11.5 vs ≥11.5.
Stratification factor: <150 vs ≥150.