Association between clinical and biological variables and High-M phenotype in SMZL patients
| Variables . | High-M phenotype . | Low-M phenotype . | Fisher’s exact test . | Pearson χ2 . |
|---|---|---|---|---|
| Notch pathway mutation | 10/21 (48%) | 7/46 (15%) | .0072a | .0047b |
| NOTCH2 mutation | 8/21 (38%) | 4/46 (9%) | .0063a | .0036b |
| IGHV1-02 usage | 8/22 (36%) | 8/65 (12%) | .0225a | .0118a |
| HCV status | 2/26 (8%) | 11/58 (19%) | .3273d | .1866d |
| High grade transformation | 5/13 (38%) | 0/47 (0%) | .0002c | <.0001c |
| Increased LDH | 8/18 (44%) | 11/44 (25%) | .1445d | .1317d |
| 7q31.32 loss | 12/28 (43%) | 13/74 (18%) | .0184a | .0081a |
| 17p loss | 5/28 (18%) | 11/74 (15%) | .7631d | .7108d |
| age <60 y | 16/22 (73%) | 60/85 (71%) | 1.0000d | .8437d |
| IILSS* | 11/16 (69%) | 19/39 (49%) | .2374d | .1754d |
| KM3 phenotype | 33/33 (100%) | 5/102 (5%) | <.0001c | <.0001c |
| KLF4 (cg07309102) | 31/33 (94%) | 9/101 (9%) | <.0001c | <.0001c |
| CACNB2 (cg01805540) | 30/33 (91%) | 18/101 (18%) | <.0001c | <.0001c |
| HTRA1 (cg25920792) | 31/33 (94%) | 11/101 (11%) | <.0001c | <.0001c |
| Variables . | High-M phenotype . | Low-M phenotype . | Fisher’s exact test . | Pearson χ2 . |
|---|---|---|---|---|
| Notch pathway mutation | 10/21 (48%) | 7/46 (15%) | .0072a | .0047b |
| NOTCH2 mutation | 8/21 (38%) | 4/46 (9%) | .0063a | .0036b |
| IGHV1-02 usage | 8/22 (36%) | 8/65 (12%) | .0225a | .0118a |
| HCV status | 2/26 (8%) | 11/58 (19%) | .3273d | .1866d |
| High grade transformation | 5/13 (38%) | 0/47 (0%) | .0002c | <.0001c |
| Increased LDH | 8/18 (44%) | 11/44 (25%) | .1445d | .1317d |
| 7q31.32 loss | 12/28 (43%) | 13/74 (18%) | .0184a | .0081a |
| 17p loss | 5/28 (18%) | 11/74 (15%) | .7631d | .7108d |
| age <60 y | 16/22 (73%) | 60/85 (71%) | 1.0000d | .8437d |
| IILSS* | 11/16 (69%) | 19/39 (49%) | .2374d | .1754d |
| KM3 phenotype | 33/33 (100%) | 5/102 (5%) | <.0001c | <.0001c |
| KLF4 (cg07309102) | 31/33 (94%) | 9/101 (9%) | <.0001c | <.0001c |
| CACNB2 (cg01805540) | 30/33 (91%) | 18/101 (18%) | <.0001c | <.0001c |
| HTRA1 (cg25920792) | 31/33 (94%) | 11/101 (11%) | <.0001c | <.0001c |
LDH, lactate dehydrogenase.
For IILSS, the comparison was high and intermediate value vs low value: a, P < .05; b, P < .005; c, P < .0005; d, borderline significance.