Indications for initiation of therapy in patients with WM
| Clinical indications for initiation of therapy |
| Recurrent fever, night sweats, weight loss, fatigue |
| Hyperviscosity |
| Lympadenopathy which is either symptomatic or bulky (≥5 cm in maximum diameter) |
| Symptomatic hepatomegaly and/or splenomegaly |
| Symptomatic organomegaly and/or organ or tissue infiltration |
| Peripheral neuropathy due to WM |
| Laboratory indications for initiation of therapy |
| Symptomatic cryglobulinemia |
| Cold agglutinin anemia |
| Immune hemolytic anemia and/or thrombocytopenia |
| Nephropathy related to WM |
| Amyloidosis related to WM |
| Hemoglobin ≤10 g/dL |
| Platelet count <100 × 109/L |
| Clinical indications for initiation of therapy |
| Recurrent fever, night sweats, weight loss, fatigue |
| Hyperviscosity |
| Lympadenopathy which is either symptomatic or bulky (≥5 cm in maximum diameter) |
| Symptomatic hepatomegaly and/or splenomegaly |
| Symptomatic organomegaly and/or organ or tissue infiltration |
| Peripheral neuropathy due to WM |
| Laboratory indications for initiation of therapy |
| Symptomatic cryglobulinemia |
| Cold agglutinin anemia |
| Immune hemolytic anemia and/or thrombocytopenia |
| Nephropathy related to WM |
| Amyloidosis related to WM |
| Hemoglobin ≤10 g/dL |
| Platelet count <100 × 109/L |