Known frequency of genetic mutations seen in MDS/MPN (% mutated)
. | Gene . | CMML21,30,-32,45,55,-57 . | JMML26,27,58,,-61 . | RARS-T29,36,62,-64 . | aCML35,54,65,66 . | MDS/MPN-U46,53 . |
---|---|---|---|---|---|---|
Cell signaling | ||||||
JAK2 V617F | 5-10 | — | 58.7 | 7 | — | |
JAK3 | <1 | 9 | — | — | — | |
CALR | — | — | 13 | — | — | |
MPL | 0 | — | 2 | — | — | |
NRAS | 4-10 | 12 | — | 8-35 | 2-14 | |
KRAS | 7-10 | 12 | — | 2 | 0 | |
PTPN11 | 2 | 40 | — | — | — | |
NF1 | 1 | 11 | — | — | — | |
FLT3 | <5 | — | — | — | — | |
CSF3R | <5 | — | — | <10 | — | |
CBL | 10-14 | 14 | — | 7 | 2 | |
KIT | <1 | — | — | — | — | |
Epigenetic regulators | ||||||
TET2 | 50-60 | — | 9-26 | 25 | 18 | |
ASXL1 | 35-40 | 4 | 10 | 25 | 14 | |
DNMT3A | <5 | — | 17 | — | 3 | |
IDH1 | <1 | — | — | — | 0 | |
IDH2 | <1 | — | — | — | 0 | |
UTX | 8 | — | — | — | — | |
EZH2 | 5-13 | 0 | 25 | 13-15 | 6-10 | |
SETBP1 | 5-10 | 7 | — | 25 | — | |
RNA splicing | ||||||
SF3B1 | 5-10 | — | 72 | — | 1 | |
U2AF1 | 5 | — | — | — | 1 | |
SRSF2 | 50 | — | — | — | 2 | |
Other | ||||||
NPM1 | <1-3 | — | — | — | — | |
TP53 | 5 | — | — | — | 4 | |
RUNX1 | 15 | — | — | 2 | — |
. | Gene . | CMML21,30,-32,45,55,-57 . | JMML26,27,58,,-61 . | RARS-T29,36,62,-64 . | aCML35,54,65,66 . | MDS/MPN-U46,53 . |
---|---|---|---|---|---|---|
Cell signaling | ||||||
JAK2 V617F | 5-10 | — | 58.7 | 7 | — | |
JAK3 | <1 | 9 | — | — | — | |
CALR | — | — | 13 | — | — | |
MPL | 0 | — | 2 | — | — | |
NRAS | 4-10 | 12 | — | 8-35 | 2-14 | |
KRAS | 7-10 | 12 | — | 2 | 0 | |
PTPN11 | 2 | 40 | — | — | — | |
NF1 | 1 | 11 | — | — | — | |
FLT3 | <5 | — | — | — | — | |
CSF3R | <5 | — | — | <10 | — | |
CBL | 10-14 | 14 | — | 7 | 2 | |
KIT | <1 | — | — | — | — | |
Epigenetic regulators | ||||||
TET2 | 50-60 | — | 9-26 | 25 | 18 | |
ASXL1 | 35-40 | 4 | 10 | 25 | 14 | |
DNMT3A | <5 | — | 17 | — | 3 | |
IDH1 | <1 | — | — | — | 0 | |
IDH2 | <1 | — | — | — | 0 | |
UTX | 8 | — | — | — | — | |
EZH2 | 5-13 | 0 | 25 | 13-15 | 6-10 | |
SETBP1 | 5-10 | 7 | — | 25 | — | |
RNA splicing | ||||||
SF3B1 | 5-10 | — | 72 | — | 1 | |
U2AF1 | 5 | — | — | — | 1 | |
SRSF2 | 50 | — | — | — | 2 | |
Other | ||||||
NPM1 | <1-3 | — | — | — | — | |
TP53 | 5 | — | — | — | 4 | |
RUNX1 | 15 | — | — | 2 | — |