Predictors of transplant-related mortality
| Predictor . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| Hazard ratio . | P value . | Hazard ratio . | P value . | |
| Age (years) | 0.99 (0.96-1.03) | .753 | ||
| Gender (female) | 1.18 (0.49-2.79) | .708 | ||
| Underlying disease (leukemia vs other) | 0.65 (0.26-1.55) | .338 | ||
| Pretransplant comorbidity (HCT-CI >3) | 2.58 (1.05-6.14) | .040 | 1.85 (0.72-4.65) | .195 |
| Disease risk* | ||||
| Low | 1.0 | — | ||
| Intermediate | 2.02 (0.63-6.49) | .229 | ||
| High | 1.14 (0.41-3.40) | .803 | ||
| Conditioning intensity | ||||
| Nonmyeloablative | 1.0 | — | ||
| Reduced intensity | 1.78 (0.51-8.12) | .378 | ||
| Myeloablative | 1.36 (0.41-6.05) | .635 | ||
| Stem cell source | ||||
| Related identical sibling | 1.0 | — | ||
| Unrelated identical | 0.71 (0.19-2.35) | .581 | ||
| Unrelated nonidentical | 1.66 (0.36-5.97) | .480 | ||
| Cord blood | 1.91 (0.65-5.59) | .230 | ||
| T-cell depletion (ex-vivo) | 0.98 (0.41-2.33) | .969 | ||
| Time to engraftment (≥4 d post-HSCT) | 1.61 (0.57-3.97) | .344 | ||
| Ursodeoxycholic acid† | 0.85 (0.25-2.31) | .774 | ||
| Liver dysfunction (total bilirubin > twice baseline)† | 1.32 (0.31-3.90) | .668 | ||
| Acute kidney injury (creatinine > twice baseline)† | 1.88 (0.74-4.46) | .175 | 1.32 (0.48-3.42) | .572 |
| TPN† | 2.15 (0.73-9.20) | .179 | 1.68 (0.50-7.76) | .426 |
| Antibiotics† | ||||
| Vancomycin (intravenous) | 2.65 (0.55-47.46) | .269 | ||
| Fluoroquinolone‡ | 0.50 (0.14-1.36) | .186 | 0.43 (0.12-1.24) | .124 |
| Metronidazole | 1.43 (0.54-3.45) | .446 | ||
| β-lactam§ | 4.89 (1.02-87.84) | .047 | 1.65 (0.28-31.89) | .630 |
| Infections† | ||||
| C difficile infection | 1.00 (0.29-2.71) | .998 | ||
| Gram-negative bloodstream infection | 1.35 (0.32-4.00) | .643 | ||
| VRE bloodstream infection | 1.79 (0.29-6.19) | .468 | ||
| Microbial diversity (engraftment) | ||||
| High diversity (inverse Simpson >4) | 1.0 | — | 1.0 | — |
| Intermediate diversity (inverse Simpson 2-4) | 3.07 (0.60-22.14) | .179 | 3.02 (0.56-22.92) | .202 |
| Low diversity (inverse Simpson <2) | 7.54 (2.12-47.88) | .001 | 5.25 (1.36-35.07) | .014 |
| Predictor . | Univariate . | Multivariate . | ||
|---|---|---|---|---|
| Hazard ratio . | P value . | Hazard ratio . | P value . | |
| Age (years) | 0.99 (0.96-1.03) | .753 | ||
| Gender (female) | 1.18 (0.49-2.79) | .708 | ||
| Underlying disease (leukemia vs other) | 0.65 (0.26-1.55) | .338 | ||
| Pretransplant comorbidity (HCT-CI >3) | 2.58 (1.05-6.14) | .040 | 1.85 (0.72-4.65) | .195 |
| Disease risk* | ||||
| Low | 1.0 | — | ||
| Intermediate | 2.02 (0.63-6.49) | .229 | ||
| High | 1.14 (0.41-3.40) | .803 | ||
| Conditioning intensity | ||||
| Nonmyeloablative | 1.0 | — | ||
| Reduced intensity | 1.78 (0.51-8.12) | .378 | ||
| Myeloablative | 1.36 (0.41-6.05) | .635 | ||
| Stem cell source | ||||
| Related identical sibling | 1.0 | — | ||
| Unrelated identical | 0.71 (0.19-2.35) | .581 | ||
| Unrelated nonidentical | 1.66 (0.36-5.97) | .480 | ||
| Cord blood | 1.91 (0.65-5.59) | .230 | ||
| T-cell depletion (ex-vivo) | 0.98 (0.41-2.33) | .969 | ||
| Time to engraftment (≥4 d post-HSCT) | 1.61 (0.57-3.97) | .344 | ||
| Ursodeoxycholic acid† | 0.85 (0.25-2.31) | .774 | ||
| Liver dysfunction (total bilirubin > twice baseline)† | 1.32 (0.31-3.90) | .668 | ||
| Acute kidney injury (creatinine > twice baseline)† | 1.88 (0.74-4.46) | .175 | 1.32 (0.48-3.42) | .572 |
| TPN† | 2.15 (0.73-9.20) | .179 | 1.68 (0.50-7.76) | .426 |
| Antibiotics† | ||||
| Vancomycin (intravenous) | 2.65 (0.55-47.46) | .269 | ||
| Fluoroquinolone‡ | 0.50 (0.14-1.36) | .186 | 0.43 (0.12-1.24) | .124 |
| Metronidazole | 1.43 (0.54-3.45) | .446 | ||
| β-lactam§ | 4.89 (1.02-87.84) | .047 | 1.65 (0.28-31.89) | .630 |
| Infections† | ||||
| C difficile infection | 1.00 (0.29-2.71) | .998 | ||
| Gram-negative bloodstream infection | 1.35 (0.32-4.00) | .643 | ||
| VRE bloodstream infection | 1.79 (0.29-6.19) | .468 | ||
| Microbial diversity (engraftment) | ||||
| High diversity (inverse Simpson >4) | 1.0 | — | 1.0 | — |
| Intermediate diversity (inverse Simpson 2-4) | 3.07 (0.60-22.14) | .179 | 3.02 (0.56-22.92) | .202 |
| Low diversity (inverse Simpson <2) | 7.54 (2.12-47.88) | .001 | 5.25 (1.36-35.07) | .014 |