Table 4 Pharmacokinetics of... | American Society of Hematology

Table 4

Pharmacokinetics of mogamulizumab following the first and fourth weekly doses in phase 1

Dose	Week	No. of patients	Mean ± standard deviation
Dose	Week	No. of patients	T_max (h)	C_max (ng/mL)	C_trough (µg/mL)	AUC_0-7days (µg/h per mL)	t_1/2 (h)	R
0.1 mg/kg	1	3	2.11 ± 2.76	1.52 ± 0.769	0.436 ± 0.288	122 ± 758	130 ± 16.4	–
	4	3	3.08 ± 1.73	2.72 ± 2.02	0.116*	301 ± 254	350 ± 270	2.17 ± 1.01
0.3 mg/kg	1	3	2.41 ± 1.15	4.90 ± 0.595	1.91 ± 0.45	468 ± 97.8	184 ± 51.9	–
	4	3	2.51 ± 1.16	13.6 ± 2.76	7.07†	1440†	430†	3.05†
1.0 mg/kg	1	3	1.74 ± 0.583	14.7 ± 4.78	4.42 ± 1.18	1050 ± 221	184 ± 64.4	–
	4	3	2.54 ± 0.50	18.8 ± 4.14	8.33 ± 2.18	1970 ± 342	334 ± 84.3	1.88 ± 0.075

Dose	Week	No. of patients	Mean ± standard deviation
Dose	Week	No. of patients	T_max (h)	C_max (ng/mL)	C_trough (µg/mL)	AUC_0-7days (µg/h per mL)	t_1/2 (h)	R
0.1 mg/kg	1	3	2.11 ± 2.76	1.52 ± 0.769	0.436 ± 0.288	122 ± 758	130 ± 16.4	–
	4	3	3.08 ± 1.73	2.72 ± 2.02	0.116*	301 ± 254	350 ± 270	2.17 ± 1.01
0.3 mg/kg	1	3	2.41 ± 1.15	4.90 ± 0.595	1.91 ± 0.45	468 ± 97.8	184 ± 51.9	–
	4	3	2.51 ± 1.16	13.6 ± 2.76	7.07†	1440†	430†	3.05†
1.0 mg/kg	1	3	1.74 ± 0.583	14.7 ± 4.78	4.42 ± 1.18	1050 ± 221	184 ± 64.4	–
	4	3	2.54 ± 0.50	18.8 ± 4.14	8.33 ± 2.18	1970 ± 342	334 ± 84.3	1.88 ± 0.075

R, accumulation ratio (fourth dose/first dose for AUC_0-7days); T_max, time to C_max.

n = 1.

n = 2.