Clinical and histological findings of mixed histiocytosis patients from the literature
| . | Reference . | Sex . | Age at onset (y) . | Time between LCH and ECD diagnosis (y) . | LCH organ involvement . | Unspecific lesions . | ECD organ involvement . | LCH histology . | ECD histology . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 19 | F | 63 | ND | Bone, skin | Hypophysis | Bone | Bone* | Bone* |
| 2 | 14 (case 2) | F | 20 | ND | Skin | E | RPF, lung, bone, skin | Skin | Skin |
| 3 | 20 | M | 65 | 0 | CNS | RPF, lung, heart | CNS | Heart | |
| 4 | 26 | F | 45 | 0 | Bone, skin | Hypophysis | Bone, skin | Skin | Skin |
| 5 | 21 | M | 58 | 0 | Bone | Hypophysis | Lung, bone, peritoneum | Bone | Lung, peritoneum |
| 6 | 15 | F | 40 | 0 | Bone, skin | E | Bone, skin | Bone | Breast |
| 7 | 13 (Case 9) | F | 41 | 0 | Bone | Bone, RPF | Bone* | Bone* | |
| 8 | 23 | F | 31 | 0 | Bone | Hypophysis | Bone | Bone* | Bone* |
| 9 | 24 (case 2) | F | 32 | 0 | Bone | E | Hypophysis | Bone | Sellar mass |
| 10 | 18 | M | 66 | 0 | Bone | Bone, skin | Bone* | Bone* | |
| 11 | 22 | F | 39 | 9 | Bone | Hypophysis | Bone, skin | Bone | Bone, * skin |
| 12 | 16 | M | 27 | 4 | Bone, lymph node | Hypophysis | Bone, joint | Lymph node | Joint |
| 13 | 25 | F | 34 | 26 | Skin | Hypophysis | RPF, bone, skin | Skin* | Skin* |
| 14 | 17 (case 1) | M | 44 | 10 | Bone | Hypophysis, E | CNS, bone | ND | CNS |
| 15 | 24 (case 1) | F | 26 | 1 | Bone, skin | Hypophysis, E | Heart, skin | Skin | Orbit, skin |
| 16 | 27 | F | 27 | 5 | Bone | Hypophysis, E | Lung, bone, skin | Skin | Orbit |
| 17 | 17 (case 2) | M | 35 | −3 | Skin | Hypophysis | Lung, bone | Skin | Bone |
| . | Reference . | Sex . | Age at onset (y) . | Time between LCH and ECD diagnosis (y) . | LCH organ involvement . | Unspecific lesions . | ECD organ involvement . | LCH histology . | ECD histology . |
|---|---|---|---|---|---|---|---|---|---|
| 1 | 19 | F | 63 | ND | Bone, skin | Hypophysis | Bone | Bone* | Bone* |
| 2 | 14 (case 2) | F | 20 | ND | Skin | E | RPF, lung, bone, skin | Skin | Skin |
| 3 | 20 | M | 65 | 0 | CNS | RPF, lung, heart | CNS | Heart | |
| 4 | 26 | F | 45 | 0 | Bone, skin | Hypophysis | Bone, skin | Skin | Skin |
| 5 | 21 | M | 58 | 0 | Bone | Hypophysis | Lung, bone, peritoneum | Bone | Lung, peritoneum |
| 6 | 15 | F | 40 | 0 | Bone, skin | E | Bone, skin | Bone | Breast |
| 7 | 13 (Case 9) | F | 41 | 0 | Bone | Bone, RPF | Bone* | Bone* | |
| 8 | 23 | F | 31 | 0 | Bone | Hypophysis | Bone | Bone* | Bone* |
| 9 | 24 (case 2) | F | 32 | 0 | Bone | E | Hypophysis | Bone | Sellar mass |
| 10 | 18 | M | 66 | 0 | Bone | Bone, skin | Bone* | Bone* | |
| 11 | 22 | F | 39 | 9 | Bone | Hypophysis | Bone, skin | Bone | Bone, * skin |
| 12 | 16 | M | 27 | 4 | Bone, lymph node | Hypophysis | Bone, joint | Lymph node | Joint |
| 13 | 25 | F | 34 | 26 | Skin | Hypophysis | RPF, bone, skin | Skin* | Skin* |
| 14 | 17 (case 1) | M | 44 | 10 | Bone | Hypophysis, E | CNS, bone | ND | CNS |
| 15 | 24 (case 1) | F | 26 | 1 | Bone, skin | Hypophysis, E | Heart, skin | Skin | Orbit, skin |
| 16 | 27 | F | 27 | 5 | Bone | Hypophysis, E | Lung, bone, skin | Skin | Orbit |
| 17 | 17 (case 2) | M | 35 | −3 | Skin | Hypophysis | Lung, bone | Skin | Bone |
E, exophtalmos; F, female; M, male; RPF, retroperitoneal fibrosis.
Presence of both LCH and ECD lesion in the same biopsy.