Table 1 Characteristics of patients with... | American Society of Hematology

Table 1

Characteristics of patients with MH and comparison with isolated-LCH and isolated-ECD patients

Characteristic							Univariate P		Multivariate P
	LCH		MH		ECD		MH vs LCH	MH vs ECD	MH vs LCH	MH vs ECD
	No.	%	No.	%	No.	%	MH vs LCH	MH vs ECD	MH vs LCH	MH vs ECD
Total No. of patients	56	100	23	100	53	100
Epidemiological data
No. of males (% of total)	30	54	11	48	39	74	.81	.038	—
Age at diagnosis, y							.002	.02	.028	NS
Median	30		43		57
Range	2-79		2-75		16-80
Follow-up from diagnosis, mo
Median	55		60		38
Range	2-429		2-408		1-189
Clinical presentation
LCH
Lytic bone lesions	37	66	16	70	—		1.00	—	NS
Cutaneous and mucosal involvement	13	23	14	61	—		.0034	—	.024
Pulmonary involvement	26	46	3	13	—		.0052	—	NS
Digestive organ involvement	4	7	4	17	—		.21	—	—
Secondary lymphoid organ involvement	nd		5	22	—		—	—	—
Unspecific lesions
CNS involvement	10	18	11	48	27	51	.011	1.00	NS	—
Hypophyseal involvement	16	29	13	57	12	23	.024	.0034	NS	NS
Orbital involvement	4	7	8	35	13	25	.004	.41	NS	—
ECD
Condensing bone lesions	—		21	91	51	96	—	.58	—	—
Cardiac involvement	—		8	35	34	64	—	.024	—	NS
Large vessel involvement	—		15	65	35	66	—	1.00	—	—
Cutaneous and mucosal involvement	—		8	35	15	28	—	.60	—	—
Pulmonary involvement	—		6	26	23	43	—	.20	—	NS
Retroperitoneal infiltration	—		13	56	36	68	—	.44	—	—
Other (epiploon)	—		1	4	nd	nd	—	—	—	—

Characteristic							Univariate P		Multivariate P
	LCH		MH		ECD		MH vs LCH	MH vs ECD	MH vs LCH	MH vs ECD
	No.	%	No.	%	No.	%	MH vs LCH	MH vs ECD	MH vs LCH	MH vs ECD
Total No. of patients	56	100	23	100	53	100
Epidemiological data
No. of males (% of total)	30	54	11	48	39	74	.81	.038	—
Age at diagnosis, y							.002	.02	.028	NS
Median	30		43		57
Range	2-79		2-75		16-80
Follow-up from diagnosis, mo
Median	55		60		38
Range	2-429		2-408		1-189
Clinical presentation
LCH
Lytic bone lesions	37	66	16	70	—		1.00	—	NS
Cutaneous and mucosal involvement	13	23	14	61	—		.0034	—	.024
Pulmonary involvement	26	46	3	13	—		.0052	—	NS
Digestive organ involvement	4	7	4	17	—		.21	—	—
Secondary lymphoid organ involvement	nd		5	22	—		—	—	—
Unspecific lesions
CNS involvement	10	18	11	48	27	51	.011	1.00	NS	—
Hypophyseal involvement	16	29	13	57	12	23	.024	.0034	NS	NS
Orbital involvement	4	7	8	35	13	25	.004	.41	NS	—
ECD
Condensing bone lesions	—		21	91	51	96	—	.58	—	—
Cardiac involvement	—		8	35	34	64	—	.024	—	NS
Large vessel involvement	—		15	65	35	66	—	1.00	—	—
Cutaneous and mucosal involvement	—		8	35	15	28	—	.60	—	—
Pulmonary involvement	—		6	26	23	43	—	.20	—	NS
Retroperitoneal infiltration	—		13	56	36	68	—	.44	—	—
Other (epiploon)	—		1	4	nd	nd	—	—	—	—

Personal data from two centers: Pitié-Salpêtrière Hospital, Paris, France, and Hôtel Dieu, Nantes, France. Bold values are statistically significant.

MH, mixed histiocytosis; ND, not determined; NS, not significant.