Adjusted rates of first VTE in splenectomized patients
| . | No. of patients . | Events . | Incidence rates per 100 person-years . | Unadjusted (univariable) . | Adjusted (multivariable) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. . | % . | Value . | 95% CI . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | ||
| Sex | |||||||||||
| Male | 1325 | 68 | 5.1 | 1.17 | 0.92 to 1.48 | 1 | 1 | ||||
| Female | 1147 | 74 | 6.5 | 1.45 | 1.15 to 1.82 | 1.25 | 0.90 to 1.74 | .179 | 1.17 | 0.84 to 1.63 | .366 |
| Age group (y) | |||||||||||
| <50 | 947 | 27 | 2.9 | 0.62 | 0.42 to 0.90 | 1 | 1 | ||||
| 50+ | 1525 | 115 | 7.5 | 1.75 | 1.46 to 2.11 | 2.75 | 1.81 to 4.18 | <.001 | 2.57 | 1.62 to 4.09 | <.001 |
| Splenectomy indication | |||||||||||
| Therapeutic malignancy | 269 | 21 | 7.8 | 1.74 | 1.14 to 2.67 | 2.23 | 1.23 to 4.06 | .008 | 1.32 | 0.70 to 2.49 | .395 |
| Therapeutic hematologic | 583 | 36 | 6.2 | 1.33 | 0.96 to 1.85 | 1.75 | 1.03 to 2.98 | .038 | 1.28 | 0.74 to 2.22 | .372 |
| Therapeutic other | 138 | 8 | 5.8 | 1.35 | 0.67 to 2.70 | 1.68 | 0.75 to 3.76 | .211 | 1.38 | 0.61 to 3.12 | .438 |
| Iatrogenic noncancer | 350 | 16 | 4.6 | 1.01 | 0.62 to 1.64 | 1.30 | 0.68 to 2.47 | .426 | 0.80 | 0.41 to 1.57 | .514 |
| Iatrogenic cancer | 497 | 39 | 7.9 | 1.89 | 1.38 to 2.58 | 2.32 | 1.38 to 3.91 | .002 | 1.30 | 0.73 to 2.30 | .371 |
| Trauma | 635 | 22 | 3.5 | 0.79 | 0.52 to 1.20 | 1 | 1 | ||||
| . | No. of patients . | Events . | Incidence rates per 100 person-years . | Unadjusted (univariable) . | Adjusted (multivariable) . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| No. . | % . | Value . | 95% CI . | HR . | 95% CI . | P . | HR . | 95% CI . | P . | ||
| Sex | |||||||||||
| Male | 1325 | 68 | 5.1 | 1.17 | 0.92 to 1.48 | 1 | 1 | ||||
| Female | 1147 | 74 | 6.5 | 1.45 | 1.15 to 1.82 | 1.25 | 0.90 to 1.74 | .179 | 1.17 | 0.84 to 1.63 | .366 |
| Age group (y) | |||||||||||
| <50 | 947 | 27 | 2.9 | 0.62 | 0.42 to 0.90 | 1 | 1 | ||||
| 50+ | 1525 | 115 | 7.5 | 1.75 | 1.46 to 2.11 | 2.75 | 1.81 to 4.18 | <.001 | 2.57 | 1.62 to 4.09 | <.001 |
| Splenectomy indication | |||||||||||
| Therapeutic malignancy | 269 | 21 | 7.8 | 1.74 | 1.14 to 2.67 | 2.23 | 1.23 to 4.06 | .008 | 1.32 | 0.70 to 2.49 | .395 |
| Therapeutic hematologic | 583 | 36 | 6.2 | 1.33 | 0.96 to 1.85 | 1.75 | 1.03 to 2.98 | .038 | 1.28 | 0.74 to 2.22 | .372 |
| Therapeutic other | 138 | 8 | 5.8 | 1.35 | 0.67 to 2.70 | 1.68 | 0.75 to 3.76 | .211 | 1.38 | 0.61 to 3.12 | .438 |
| Iatrogenic noncancer | 350 | 16 | 4.6 | 1.01 | 0.62 to 1.64 | 1.30 | 0.68 to 2.47 | .426 | 0.80 | 0.41 to 1.57 | .514 |
| Iatrogenic cancer | 497 | 39 | 7.9 | 1.89 | 1.38 to 2.58 | 2.32 | 1.38 to 3.91 | .002 | 1.30 | 0.73 to 2.30 | .371 |
| Trauma | 635 | 22 | 3.5 | 0.79 | 0.52 to 1.20 | 1 | 1 | ||||
HR, hazard ratio.