Table 1

Patient and graft demographics of 113 DCBT recipients and 226 units

CharacteristicsValue
Median age (range), y 41 (1-69) 
Male, N (%) 61 (54) 
Recipient CMV seropositive, N (%) 61 (54) 
Diagnosis, N (%)  
 Acute leukemia 58 (51) 
 MDS/CML/other MPD 8 (7) 
 NHL/HL/CLL 47 (42) 
Conditioning, N (%)  
 High-dose myeloablative  
  Cy 120/Flu 75/TBI 1320-1375 cGy 32 (28) 
  Clo 100/Mel 140/Thio 10 5 (4) 
 Reduced intensity  
  Cy 50/Flu 150/Thio 10/TBI 400 cGy 39 (35) 
  Mel 140/Flu 150 8 (7) 
 Nonmyeloablative  
  Cy 50/Flu 150/TBI 200 cGy 28 (25) 
  6-TG, Flu 150/TBI 400 cGy 1 (1) 
Donor-recipient HLA-A, -B antigen, -DRB1 allele match, N (%)  
 6/6 9 (4) 
 5/6 115 (51) 
 4/6 102 (45) 
Median infused TNC dose (range)  
 Larger unit 2.76 × 107/kg (1.46-7.19) 
 Smaller unit 2.02 × 107/kg (1.13-4.51) 
Median infused CD34+dose (range)  
 Larger unit 1.33 × 105/kg (0.41-4.51) 
 Smaller unit 0.68 × 105/kg (0.13-2.0) 
CharacteristicsValue
Median age (range), y 41 (1-69) 
Male, N (%) 61 (54) 
Recipient CMV seropositive, N (%) 61 (54) 
Diagnosis, N (%)  
 Acute leukemia 58 (51) 
 MDS/CML/other MPD 8 (7) 
 NHL/HL/CLL 47 (42) 
Conditioning, N (%)  
 High-dose myeloablative  
  Cy 120/Flu 75/TBI 1320-1375 cGy 32 (28) 
  Clo 100/Mel 140/Thio 10 5 (4) 
 Reduced intensity  
  Cy 50/Flu 150/Thio 10/TBI 400 cGy 39 (35) 
  Mel 140/Flu 150 8 (7) 
 Nonmyeloablative  
  Cy 50/Flu 150/TBI 200 cGy 28 (25) 
  6-TG, Flu 150/TBI 400 cGy 1 (1) 
Donor-recipient HLA-A, -B antigen, -DRB1 allele match, N (%)  
 6/6 9 (4) 
 5/6 115 (51) 
 4/6 102 (45) 
Median infused TNC dose (range)  
 Larger unit 2.76 × 107/kg (1.46-7.19) 
 Smaller unit 2.02 × 107/kg (1.13-4.51) 
Median infused CD34+dose (range)  
 Larger unit 1.33 × 105/kg (0.41-4.51) 
 Smaller unit 0.68 × 105/kg (0.13-2.0) 

6-TG, 6-thioguanine; CLL, chronic lymphocytic leukemia; Clo, clofarabine; CML, chronic myelogenous leukemia; CMV, cytomegalovirus; Cy, cyclophosphamide; Flu, fludarabine; HL, Hodgkin lymphoma; MDS, myelodysplastic syndrome; Mel, melphalan; MPD, myeloproliferative disease; NHL, non-Hodgkin lymphoma; TBI, total body irradiation; Thio, Thiotepa; TNC, total nucleated cell dose.

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