Multivariate Cox regression models for genetic risk based on 742 BCP patients treated on UKALL2003
| . | HR . | 99% CI . | P . |
|---|---|---|---|
| EFS | |||
| Genetic risk group: poor vs good | 3.29 | 1.49-7.27 | <.001 |
| Age (y)* | 1.03 | 0.96-1.11 | .2 |
| WCC* | 1.22 | 0.94-1.57 | .04 |
| MRD risk group: high vs low | 4.05 | 1.61-10.13 | <.001 |
| Relapse risk | |||
| Genetic risk group: poor vs good | 3.68 | 1.47-9.20 | <.001 |
| Age (y)* | 1.04 | 0.95-1.13 | .2 |
| WCC* | 1.19 | 0.89-1.60 | .1 |
| MRD risk group: high vs low | 4.46 | 1.50-13.22 | <.001 |
| OS | |||
| Genetic risk group: poor vs good | 4.96 | 1.68-14.61 | <.001 |
| Age (y)* | 1.06 | 0.98-1.16 | .04 |
| WCC* | 1.31 | 0.97-1.78 | .02 |
| MRD risk group: high vs low | 4.66 | 1.31-16.54 | .002 |
| . | HR . | 99% CI . | P . |
|---|---|---|---|
| EFS | |||
| Genetic risk group: poor vs good | 3.29 | 1.49-7.27 | <.001 |
| Age (y)* | 1.03 | 0.96-1.11 | .2 |
| WCC* | 1.22 | 0.94-1.57 | .04 |
| MRD risk group: high vs low | 4.05 | 1.61-10.13 | <.001 |
| Relapse risk | |||
| Genetic risk group: poor vs good | 3.68 | 1.47-9.20 | <.001 |
| Age (y)* | 1.04 | 0.95-1.13 | .2 |
| WCC* | 1.19 | 0.89-1.60 | .1 |
| MRD risk group: high vs low | 4.46 | 1.50-13.22 | <.001 |
| OS | |||
| Genetic risk group: poor vs good | 4.96 | 1.68-14.61 | <.001 |
| Age (y)* | 1.06 | 0.98-1.16 | .04 |
| WCC* | 1.31 | 0.97-1.78 | .02 |
| MRD risk group: high vs low | 4.66 | 1.31-16.54 | .002 |
Added to the model as continuous variables.