Patient characteristics (N = 400)
| Characteristic . | No. (%) . |
|---|---|
| Median patient age at initial treatment, range, years | 52 (1-79) |
| Patient gender | |
| Male | 220 (55) |
| Female | 180 (45) |
| Donor-patient gender combination | |
| Female to male | 108 (27) |
| Other | 292 (73) |
| Diagnosis | |
| Myeloid malignancy | 232 (58) |
| Lymphoid malignancy | 154 (39) |
| Other/nonmalignant | 14 (4) |
| Disease risk at transplantation* | |
| Low | 136 (34) |
| High | 264 (66) |
| Conditioning regimen | |
| High dose without TBI | 137 (34) |
| High dose with TBI | 81 (20) |
| Reduced intensity | 182 (46) |
| Graft source | |
| Bone marrow | 46 (12) |
| Mobilized blood cells | 332 (83) |
| Cord blood | 22 (6) |
| Donor and HLA type | |
| HLA-matched related | 147 (37) |
| HLA-matched unrelated | 155 (39) |
| HLA antigen or allele-mismatched related | 19 (5) |
| HLA antigen or allele-mismatched unrelated | 79 (20) |
| Characteristic . | No. (%) . |
|---|---|
| Median patient age at initial treatment, range, years | 52 (1-79) |
| Patient gender | |
| Male | 220 (55) |
| Female | 180 (45) |
| Donor-patient gender combination | |
| Female to male | 108 (27) |
| Other | 292 (73) |
| Diagnosis | |
| Myeloid malignancy | 232 (58) |
| Lymphoid malignancy | 154 (39) |
| Other/nonmalignant | 14 (4) |
| Disease risk at transplantation* | |
| Low | 136 (34) |
| High | 264 (66) |
| Conditioning regimen | |
| High dose without TBI | 137 (34) |
| High dose with TBI | 81 (20) |
| Reduced intensity | 182 (46) |
| Graft source | |
| Bone marrow | 46 (12) |
| Mobilized blood cells | 332 (83) |
| Cord blood | 22 (6) |
| Donor and HLA type | |
| HLA-matched related | 147 (37) |
| HLA-matched unrelated | 155 (39) |
| HLA antigen or allele-mismatched related | 19 (5) |
| HLA antigen or allele-mismatched unrelated | 79 (20) |
TBI, total body irradiation.
The low-risk category included chronic myeloid leukemia in chronic phase, acute leukemia in first remission, myelodysplastic syndrome without excess blasts, and nonmalignant diseases. The high-risk category included all other diseases and stages.