Pathologic data stratified by ALCL genetics
| Variable . | Gene rearranged, N (%) . | Total (N = 105) . | P value* . | |||
|---|---|---|---|---|---|---|
| ALK (N = 32) . | DUSP22 (N = 22) . | TP63 (N = 6) . | −/−/− (N = 45) . | |||
| Diagnosis agreement | .0148 | |||||
| 2 reviewers | 0 (0) | 1 (5) | 1 (17) | 10 (22) | 12 (11) | |
| 3 reviewers | 32 (100) | 21 (95) | 5 (83) | 35 (78) | 93 (89) | |
| Classic histology | .06421 | |||||
| <3 reviewers | 10 (32) | 2 (10) | 2 (40) | 18 (43) | 32 (32) | |
| 3 reviewers | 21 (67) | 19 (90) | 3 (60) | 24 (57) | 67 (68) | |
| TIA1 | <.0001 | |||||
| Negative | 7 (22) | 19 (90) | 3 (50) | 21 (47) | 50 (48) | |
| Positive | 25 (78) | 2 (10) | 3 (50) | 24 (53) | 54 (52) | |
| Granzyme B | .0100 | |||||
| Negative | 17 (57) | 20 (95) | 3 (50) | 24 (56) | 64 (64) | |
| Positive | 13 (43) | 1 (5) | 3 (50) | 19 (44) | 36 (36) | |
| EMA | <.0001 | |||||
| Negative | 9 (30) | 20 (100) | 5 (100) | 31 (80) | 65 (69) | |
| Positive | 21 (70) | 0 (0) | 0 (0) | 8 (20) | 29 (31) | |
| Clusterin | .0006 | |||||
| Negative | 4 (14) | 11 (61) | 3 (60) | 23 (62) | 41 (47) | |
| Positive | 24 (86) | 7 (39) | 2 (40) | 14 (38) | 47 (53) | |
| TCR βF1 | .1272 | |||||
| Negative | 12 (75) | 7 (50) | 1 (20) | 20 (65) | 40 (61) | |
| Positive | 4 (25) | 7 (50) | 4 (80) | 11 (35) | 26 (39) | |
| TCR γ-δ | .7963 | |||||
| Negative | 13 (100) | 9 (100) | 3 (100) | 24 (96) | 49 (98) | |
| Positive | 0 (0) | 0 (0) | 0 (0) | 1 (4) | 1 (2) | |
| CD2 | .0002 | |||||
| Negative | 18 (69) | 3 (17) | 0 (0) | 10 (27) | 31 (36) | |
| Positive | 8 (31) | 15 (83) | 5 (100) | 27 (73) | 55 (64) | |
| CD3 | .0004 | |||||
| Negative | 23 (74) | 4 (19) | 1 (17) | 24 (55) | 52 (51) | |
| Positive | 8 (26) | 17 (81) | 5 (83) | 20 (45) | 50 (49) | |
| CD4 | .9922 | |||||
| Negative | 10 (45) | 8 (47) | 2 (40) | 16 (47) | 36 (46) | |
| Positive | 12 (55) | 9 (53) | 3 (60) | 18 (53) | 42 (54) | |
| CD5 | .3770 | |||||
| Negative | 13 (65) | 15 (88) | 3 (60) | 26 (72) | 57 (73) | |
| Positive | 7 (35) | 2 (12) | 2 (40) | 10 (28) | 21 (27) | |
| CD8 | .4206 | |||||
| Negative | 20 (100) | 15 (88) | 5 (100) | 30 (94) | 70 (95) | |
| Positive | 0 (0) | 2 (12) | 0 (0) | 2 (6) | 4 (5) | |
| p63 | <.0001 | |||||
| Negative | 26 (96) | 13 (81) | 0 (0) | 32 (94) | 71 (85) | |
| Positive | 1 (4) | 3 (19) | 6 (100) | 2 (6) | 12 (15) | |
| Variable . | Gene rearranged, N (%) . | Total (N = 105) . | P value* . | |||
|---|---|---|---|---|---|---|
| ALK (N = 32) . | DUSP22 (N = 22) . | TP63 (N = 6) . | −/−/− (N = 45) . | |||
| Diagnosis agreement | .0148 | |||||
| 2 reviewers | 0 (0) | 1 (5) | 1 (17) | 10 (22) | 12 (11) | |
| 3 reviewers | 32 (100) | 21 (95) | 5 (83) | 35 (78) | 93 (89) | |
| Classic histology | .06421 | |||||
| <3 reviewers | 10 (32) | 2 (10) | 2 (40) | 18 (43) | 32 (32) | |
| 3 reviewers | 21 (67) | 19 (90) | 3 (60) | 24 (57) | 67 (68) | |
| TIA1 | <.0001 | |||||
| Negative | 7 (22) | 19 (90) | 3 (50) | 21 (47) | 50 (48) | |
| Positive | 25 (78) | 2 (10) | 3 (50) | 24 (53) | 54 (52) | |
| Granzyme B | .0100 | |||||
| Negative | 17 (57) | 20 (95) | 3 (50) | 24 (56) | 64 (64) | |
| Positive | 13 (43) | 1 (5) | 3 (50) | 19 (44) | 36 (36) | |
| EMA | <.0001 | |||||
| Negative | 9 (30) | 20 (100) | 5 (100) | 31 (80) | 65 (69) | |
| Positive | 21 (70) | 0 (0) | 0 (0) | 8 (20) | 29 (31) | |
| Clusterin | .0006 | |||||
| Negative | 4 (14) | 11 (61) | 3 (60) | 23 (62) | 41 (47) | |
| Positive | 24 (86) | 7 (39) | 2 (40) | 14 (38) | 47 (53) | |
| TCR βF1 | .1272 | |||||
| Negative | 12 (75) | 7 (50) | 1 (20) | 20 (65) | 40 (61) | |
| Positive | 4 (25) | 7 (50) | 4 (80) | 11 (35) | 26 (39) | |
| TCR γ-δ | .7963 | |||||
| Negative | 13 (100) | 9 (100) | 3 (100) | 24 (96) | 49 (98) | |
| Positive | 0 (0) | 0 (0) | 0 (0) | 1 (4) | 1 (2) | |
| CD2 | .0002 | |||||
| Negative | 18 (69) | 3 (17) | 0 (0) | 10 (27) | 31 (36) | |
| Positive | 8 (31) | 15 (83) | 5 (100) | 27 (73) | 55 (64) | |
| CD3 | .0004 | |||||
| Negative | 23 (74) | 4 (19) | 1 (17) | 24 (55) | 52 (51) | |
| Positive | 8 (26) | 17 (81) | 5 (83) | 20 (45) | 50 (49) | |
| CD4 | .9922 | |||||
| Negative | 10 (45) | 8 (47) | 2 (40) | 16 (47) | 36 (46) | |
| Positive | 12 (55) | 9 (53) | 3 (60) | 18 (53) | 42 (54) | |
| CD5 | .3770 | |||||
| Negative | 13 (65) | 15 (88) | 3 (60) | 26 (72) | 57 (73) | |
| Positive | 7 (35) | 2 (12) | 2 (40) | 10 (28) | 21 (27) | |
| CD8 | .4206 | |||||
| Negative | 20 (100) | 15 (88) | 5 (100) | 30 (94) | 70 (95) | |
| Positive | 0 (0) | 2 (12) | 0 (0) | 2 (6) | 4 (5) | |
| p63 | <.0001 | |||||
| Negative | 26 (96) | 13 (81) | 0 (0) | 32 (94) | 71 (85) | |
| Positive | 1 (4) | 3 (19) | 6 (100) | 2 (6) | 12 (15) | |
−/−/−, triple-negative ALCL.
χ2.