Table 1 Data sets used for HLA... | American Society of Hematology

Table 1

Data sets used for HLA association study and for HLA class II allele imputation

Data set	Sample size	% Allergy*	Asparaginase formulation	Asparaginase dose	Genotyping platform	SNPs used for HLA imputation	Imputed SNPs
T1DGC	4 871	NA	NA	NA	Illumina Immunochip	NA†	NA
Total XIIIA	91	30.8	Elspar (native E coli asparaginase)	10 000 IU/m², IM 3 times weekly (induction and reinduction phases; 18 doses) and on weeks 4, 8, 12, 16, 20, 24, and 28 of continuation	Illumina Exome Beadchip	1 814	4 753
Total XV	320	45.6	Elspar (native E coli asparaginase)	10 000-25 000 IU/m², IM 3 times weekly or once weekly (induction, continuation/reinduction; 24-28 doses)	Affymetrix 500K	578	5 989
Total XVI	130	18.5	Oncaspar (PEGylated E coli asparaginase)	2 500-3 500 IU/m², IV weekly (induction, continuation/reinduction; 5-17 doses)	Affymetrix 6.0	964	5 603
POG 9906	125	28.0	Elspar (native E coli asparaginase)	6 000-15 000 IU/m², IM 3 times weekly or once weekly (induction, consolidation, interim maintenance, delayed intensification; 52 doses)	Affymetrix 500K	578	5 989
AALL0232	1 204	11.4	Oncaspar (PEGylated E coli asparaginase)	2 500 IU/m², IM weekly (induction, consolidation, interim maintenance, delayed intensification; 6-12 doses)	Affymetrix 6.0	964	5 603

Data set	Sample size	% Allergy*	Asparaginase formulation	Asparaginase dose	Genotyping platform	SNPs used for HLA imputation	Imputed SNPs
T1DGC	4 871	NA	NA	NA	Illumina Immunochip	NA†	NA
Total XIIIA	91	30.8	Elspar (native E coli asparaginase)	10 000 IU/m², IM 3 times weekly (induction and reinduction phases; 18 doses) and on weeks 4, 8, 12, 16, 20, 24, and 28 of continuation	Illumina Exome Beadchip	1 814	4 753
Total XV	320	45.6	Elspar (native E coli asparaginase)	10 000-25 000 IU/m², IM 3 times weekly or once weekly (induction, continuation/reinduction; 24-28 doses)	Affymetrix 500K	578	5 989
Total XVI	130	18.5	Oncaspar (PEGylated E coli asparaginase)	2 500-3 500 IU/m², IV weekly (induction, continuation/reinduction; 5-17 doses)	Affymetrix 6.0	964	5 603
POG 9906	125	28.0	Elspar (native E coli asparaginase)	6 000-15 000 IU/m², IM 3 times weekly or once weekly (induction, consolidation, interim maintenance, delayed intensification; 52 doses)	Affymetrix 500K	578	5 989
AALL0232	1 204	11.4	Oncaspar (PEGylated E coli asparaginase)	2 500 IU/m², IM weekly (induction, consolidation, interim maintenance, delayed intensification; 6-12 doses)	Affymetrix 6.0	964	5 603

IM, intramuscular; NA, not available.

% Allergy is the percentage of patients with hypersensitivities to asparaginase within each data set.

A total of 7792 SNPs were available from the T1DGC data set for SNP and HLA imputation.