Patient demographics
| Patient characteristics . | Treg-Tcon . | Historical controls . | P value . |
|---|---|---|---|
| Number of patients | 43 | 114 | |
| M/F | 20/23 | 63/51 | .5 |
| Age, y (median and range) | 40 (range 18-65) | 37 (range 8-66) | .8 |
| Median time and range from diagnosis to transplant, CR1 | 6 mo (3-48) | 5 mo (2-55) | .4 |
| Median length of remission and range, CR2 | 6.5 mo (1-60) | 7 mo (2-55) | .6 |
| Disease and status | |||
| ALL | 10 (23%) | 50 (44%) | .08 |
| 1 CR | 7 | 27 | |
| ≥II CR | 3 | 23 | |
| AML | 33 (77%) | 64 (56%) | .07 |
| 1 CR | 18 | 30 | |
| ≥II CR | 15 | 34 | |
| NK cell alloreactivity | |||
| ALL | 10 | 50 | |
| Yes | 3 (30%) | 19 (38%) | .6 |
| No | 7 (70%) | 31 (62%) | .7 |
| AML | 33 | 64 | |
| Yes | 14 (43%) | 32 (50%) | .5 |
| No | 19 (57%) | 32 (50%) | .4 |
| High-risk CR1 | 25 (58%) | 67 (59%) | .8 |
| Induction failure | 2 | 7 | |
| Secondary | 1 | 10 | |
| T(9;22) | 4 | 11 | |
| Bilineage leukemia | 3 | 6 | |
| Complex karyotype | 8 | 10 | |
| FLT3 ITD | 8 | NA | |
| WBC >50 000/mmc at diagnosis for ALL | 4 | 10 |
| Patient characteristics . | Treg-Tcon . | Historical controls . | P value . |
|---|---|---|---|
| Number of patients | 43 | 114 | |
| M/F | 20/23 | 63/51 | .5 |
| Age, y (median and range) | 40 (range 18-65) | 37 (range 8-66) | .8 |
| Median time and range from diagnosis to transplant, CR1 | 6 mo (3-48) | 5 mo (2-55) | .4 |
| Median length of remission and range, CR2 | 6.5 mo (1-60) | 7 mo (2-55) | .6 |
| Disease and status | |||
| ALL | 10 (23%) | 50 (44%) | .08 |
| 1 CR | 7 | 27 | |
| ≥II CR | 3 | 23 | |
| AML | 33 (77%) | 64 (56%) | .07 |
| 1 CR | 18 | 30 | |
| ≥II CR | 15 | 34 | |
| NK cell alloreactivity | |||
| ALL | 10 | 50 | |
| Yes | 3 (30%) | 19 (38%) | .6 |
| No | 7 (70%) | 31 (62%) | .7 |
| AML | 33 | 64 | |
| Yes | 14 (43%) | 32 (50%) | .5 |
| No | 19 (57%) | 32 (50%) | .4 |
| High-risk CR1 | 25 (58%) | 67 (59%) | .8 |
| Induction failure | 2 | 7 | |
| Secondary | 1 | 10 | |
| T(9;22) | 4 | 11 | |
| Bilineage leukemia | 3 | 6 | |
| Complex karyotype | 8 | 10 | |
| FLT3 ITD | 8 | NA | |
| WBC >50 000/mmc at diagnosis for ALL | 4 | 10 |
F, female; M, male; NA, not applicable; WBC, white blood cell.