NOTCH1-activating and PTEN/AKT mutations predict for poor outcome in pediatric T-ALL treated on DCOG ALL7/8/9 or COALL-97/03 protocols
| Analyses using Cox regression model . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Univariate | ||||
| Male gender | 146 | 3.278 | 1.267-8.486 | .014* |
| TLX3 | 146 | 2.044 | 1-4.175 | .05* |
| NOTCH1/FBXW7 | 141 | 2.077 | 0.946-4.560 | .068 |
| PTEN/AKT aberrations† | 142 | 1.675 | 0.787-3.567 | .18 |
| Multivariate | ||||
| Male gender | 141 | 2.910 | 1.117-7.577 | .029* |
| TLX3 | 141 | 2.018 | 0.921-4.424 | .079 |
| NOTCH-activating | 141 | 2.588 | 1.083-6.183 | .032* |
| PTEN/AKT aberrations† | 141 | 3.407 | 1.254-7.400 | .014* |
| Analyses using Cox regression model . | n . | HR . | 95% CI . | P . |
|---|---|---|---|---|
| Univariate | ||||
| Male gender | 146 | 3.278 | 1.267-8.486 | .014* |
| TLX3 | 146 | 2.044 | 1-4.175 | .05* |
| NOTCH1/FBXW7 | 141 | 2.077 | 0.946-4.560 | .068 |
| PTEN/AKT aberrations† | 142 | 1.675 | 0.787-3.567 | .18 |
| Multivariate | ||||
| Male gender | 141 | 2.910 | 1.117-7.577 | .029* |
| TLX3 | 141 | 2.018 | 0.921-4.424 | .079 |
| NOTCH-activating | 141 | 2.588 | 1.083-6.183 | .032* |
| PTEN/AKT aberrations† | 141 | 3.407 | 1.254-7.400 | .014* |
Univariate and multivariate Cox regression analyses stratified for DCOG or COALL treatment protocols using RFS for various parameters that were significantly associated with poor RFS (see supplemental Table 7).
CI, confidence interval; HR, hazard ratio.
P value represents P < .05.
Includes T-ALL patients who do not express PTEN protein while lacking PTEN aberrations, but does not include patient samples with PTEN aberrations only on the subclonal level.