All cause adverse events ≥10% (all grade) or grade ≥3 in 2 or more patients
| . | N = 22, n (%) . | |
|---|---|---|
| All grade AEs . | Grade ≥3 AEs* . | |
| Any AE | 22 (100) | 12 (55) |
| Fatigue | 20 (91) | 2 (9) |
| Diarrhea | 16 (73) | – |
| Nausea | 15 (68) | – |
| Anemia | 11 (50) | 7 (32) |
| Fever | 10 (45) | – |
| Constipation | 9 (41) | – |
| Leukopenia | 8 (36) | – |
| Thrombocytopenia | 8 (36) | 2 (9) |
| Vomiting | 8 (36) | 2 (9) |
| Anorexia | 8 (36) | 1 (5) |
| Cough | 8 (36) | – |
| Chills | 7 (31) | – |
| Hypocalcemia | 6 (27) | – |
| Neutropenia | 5 (22) | 2 (9) |
| Respiratory infection | 5 (22) | 2 (9) |
| Dehydration | 5 (22) | 2 (9) |
| Hypotension | 5 (22) | 1 (5) |
| Weight loss | 5 (22) | 1 (5) |
| Abdominal pain | 5 (22) | – |
| Headache | 5 (22) | – |
| Dyspnea | 4 (18) | 2 (9) |
| Creatinine increase | 4 (18) | 1 (5) |
| Dysgeusia | 4 (18) | – |
| Malaise | 4 (18) | – |
| Hypoalbuminemia | 4 (18) | – |
| Peripheral edema | 4 (18) | – |
| Muscle weakness | 3 (13) | 2 (9) |
| Rash | 3 (13) | 1 (5) |
| Insomnia | 3 (13) | – |
| Paresthesia | 3 (13) | – |
| Oral dysesthesia | 3 (13) | – |
| ALT increase | 3 (13) | – |
| Back pain | 3 (13) | – |
| Sepsis | 2 (9) | 2 (9) |
| . | N = 22, n (%) . | |
|---|---|---|
| All grade AEs . | Grade ≥3 AEs* . | |
| Any AE | 22 (100) | 12 (55) |
| Fatigue | 20 (91) | 2 (9) |
| Diarrhea | 16 (73) | – |
| Nausea | 15 (68) | – |
| Anemia | 11 (50) | 7 (32) |
| Fever | 10 (45) | – |
| Constipation | 9 (41) | – |
| Leukopenia | 8 (36) | – |
| Thrombocytopenia | 8 (36) | 2 (9) |
| Vomiting | 8 (36) | 2 (9) |
| Anorexia | 8 (36) | 1 (5) |
| Cough | 8 (36) | – |
| Chills | 7 (31) | – |
| Hypocalcemia | 6 (27) | – |
| Neutropenia | 5 (22) | 2 (9) |
| Respiratory infection | 5 (22) | 2 (9) |
| Dehydration | 5 (22) | 2 (9) |
| Hypotension | 5 (22) | 1 (5) |
| Weight loss | 5 (22) | 1 (5) |
| Abdominal pain | 5 (22) | – |
| Headache | 5 (22) | – |
| Dyspnea | 4 (18) | 2 (9) |
| Creatinine increase | 4 (18) | 1 (5) |
| Dysgeusia | 4 (18) | – |
| Malaise | 4 (18) | – |
| Hypoalbuminemia | 4 (18) | – |
| Peripheral edema | 4 (18) | – |
| Muscle weakness | 3 (13) | 2 (9) |
| Rash | 3 (13) | 1 (5) |
| Insomnia | 3 (13) | – |
| Paresthesia | 3 (13) | – |
| Oral dysesthesia | 3 (13) | – |
| ALT increase | 3 (13) | – |
| Back pain | 3 (13) | – |
| Sepsis | 2 (9) | 2 (9) |
Grade ≥3 AEs occurring in 1 patient each (5%) and not mentioned above were: urinary tract infection, cellulitis, transient ischemic attack, pleural effusion, hypoxia, hypokalemia, and hyperuricemia.
AE, adverse event; ALT, alanine transaminase; –, 0 patients.