Multivariable Andersen-Gill models on RFS and OS
| . | RFS HR (95% CI) . | P value . | OS HR (95% CI) . | P value . |
|---|---|---|---|---|
| High mutant/WT ratio allo-HSCT | 1.66 (1.12-2.46) | .01 | 1.64 (1.07-2.50) | .02 |
| 0.86 (0.53-1.39) | .54 | 0.96 (0.58-1.59) | .87 | |
| (High mutant/WT ratio) × (allo-HSCT) IS TKD1 | 0.46 (0.24-0.91) | .03 | 0.49 (0.24-1.00) | .05 |
| 1.43 (0.98-2.09) | .07 | 1.37 (0.93-2.02) | .11 | |
| Mutant NPM1 FLT3-TKD | 0.90 (0.64-1.26) | .55 | 0.92 (0.64-1.31) | .63 |
| 0.53 (0.23-1.21) | .13 | 0.50 (0.20-1.25) | .14 | |
| Age (10-year difference) | 1.24 (1.05-1.46) | .01 | 1.35 (1.13-1.61) | .001 |
| Platelets (10 G/l difference) | 0.99 (0.97-1.01) | .33 | 0.98 (0.96-1.01) | .20 |
| . | RFS HR (95% CI) . | P value . | OS HR (95% CI) . | P value . |
|---|---|---|---|---|
| High mutant/WT ratio allo-HSCT | 1.66 (1.12-2.46) | .01 | 1.64 (1.07-2.50) | .02 |
| 0.86 (0.53-1.39) | .54 | 0.96 (0.58-1.59) | .87 | |
| (High mutant/WT ratio) × (allo-HSCT) IS TKD1 | 0.46 (0.24-0.91) | .03 | 0.49 (0.24-1.00) | .05 |
| 1.43 (0.98-2.09) | .07 | 1.37 (0.93-2.02) | .11 | |
| Mutant NPM1 FLT3-TKD | 0.90 (0.64-1.26) | .55 | 0.92 (0.64-1.31) | .63 |
| 0.53 (0.23-1.21) | .13 | 0.50 (0.20-1.25) | .14 | |
| Age (10-year difference) | 1.24 (1.05-1.46) | .01 | 1.35 (1.13-1.61) | .001 |
| Platelets (10 G/l difference) | 0.99 (0.97-1.01) | .33 | 0.98 (0.96-1.01) | .20 |
This has to be interpreted in the context of interactions; e.g., for RFS, the estimated HR of allogeneic HSCT compared with no allogeneic HSCT in first CR is 0.86 for low mutant/WT ratios and results in 0.86 × 0.46 = 0.39 for high mutant/WT ratios.