Adverse events at least possibly attributable to XmAb5574
| Toxicity . | 0.3 mg/kg (N = 1) . | 1 mg/kg (N = 1) . | 3 mg/kg (N = 3) . | 6 mg/kg (N = 3) . | 9 mg/kg (N = 3) . | 12 mg/kg (N = 16) . | Total (%) . |
|---|---|---|---|---|---|---|---|
| Any event | 1 | 1 | 3 | 3 | 2 | 14 | 24 (88.9) |
| DLTs | |||||||
| Grade 4 neutropenia lasting ≥7 d with febrile neutropenia | 1 | 1 (3.7) | |||||
| Other grade 3/4 toxicities | |||||||
| Neutropenia | 1 | 1 | 2(7.4) | ||||
| Thrombocytopenia | 2 | 2(7.4) | |||||
| Tumor lysis syndrome | 1 | 1(3.7) | |||||
| Increased AST | 1 | 1(3.7) | |||||
| Grade 1/2 toxicities occurring in >1 patient | |||||||
| Infusion reaction | 1 | 1 | 1 | 2 | 2 | 11 | 18(66.7) |
| Increased AST | 1 | 2 | 1 | 4(14.8) | |||
| Increased alanine aminotransferase | 2 | 1 | 2 | 5(18.5) | |||
| Neutropenia | 1 | 1 | 2(7.4) | ||||
| Thrombocytopenia | 1 | 2 | 3(11.1) | ||||
| Fever | 1 | 1 | 1 | 1 | 4(14.8) | ||
| Chills | 1 | 1 | 1 | 3(11.1) | |||
| Peripheral sensory neuropathy | 1 | 2 | 3(11.1) | ||||
| Diarrhea | 1 | 1 | 2(7.4) | ||||
| Flushing | 1 | 1 | 2(7.4) | ||||
| Hyperuricemia | 1 | 1 | 2(7.4) | ||||
| Hypocalcemia | 1 | 1 | 2(7.4) | ||||
| Increased lipase | 1 | 1 | 2(7.4) |
| Toxicity . | 0.3 mg/kg (N = 1) . | 1 mg/kg (N = 1) . | 3 mg/kg (N = 3) . | 6 mg/kg (N = 3) . | 9 mg/kg (N = 3) . | 12 mg/kg (N = 16) . | Total (%) . |
|---|---|---|---|---|---|---|---|
| Any event | 1 | 1 | 3 | 3 | 2 | 14 | 24 (88.9) |
| DLTs | |||||||
| Grade 4 neutropenia lasting ≥7 d with febrile neutropenia | 1 | 1 (3.7) | |||||
| Other grade 3/4 toxicities | |||||||
| Neutropenia | 1 | 1 | 2(7.4) | ||||
| Thrombocytopenia | 2 | 2(7.4) | |||||
| Tumor lysis syndrome | 1 | 1(3.7) | |||||
| Increased AST | 1 | 1(3.7) | |||||
| Grade 1/2 toxicities occurring in >1 patient | |||||||
| Infusion reaction | 1 | 1 | 1 | 2 | 2 | 11 | 18(66.7) |
| Increased AST | 1 | 2 | 1 | 4(14.8) | |||
| Increased alanine aminotransferase | 2 | 1 | 2 | 5(18.5) | |||
| Neutropenia | 1 | 1 | 2(7.4) | ||||
| Thrombocytopenia | 1 | 2 | 3(11.1) | ||||
| Fever | 1 | 1 | 1 | 1 | 4(14.8) | ||
| Chills | 1 | 1 | 1 | 3(11.1) | |||
| Peripheral sensory neuropathy | 1 | 2 | 3(11.1) | ||||
| Diarrhea | 1 | 1 | 2(7.4) | ||||
| Flushing | 1 | 1 | 2(7.4) | ||||
| Hyperuricemia | 1 | 1 | 2(7.4) | ||||
| Hypocalcemia | 1 | 1 | 2(7.4) | ||||
| Increased lipase | 1 | 1 | 2(7.4) |