MPN complication rates, prognosis and risk scoring algorithms
| . | ET . | PV . | PMF . |
|---|---|---|---|
| Thrombotic events | 10%–29%23 | 34%–39%23 | 7.2–13.2%65,66 |
| Bleeding events | 0.3%67 | 2.968 | – |
| Leukemic transformation | 2% at 15 y69,70 | 5.5% at 15 y27 | 6%–18%71 |
| Overall survival | 14.7 y70 | 6.5–24 y72,73 | 6–10 y28,74,75 |
| Risk algorithms | IPSET26 | Tefferi criteria27 | DIPSS PLUS2 |
| Age | ≥60 (2 pts) vs <60 | ≥67 (5 pts) 57–66 (2 pts) | ≥65 (1 pt) vs <65 |
| Leukocytes | ≥11 (1 pt) vs <11 × 109/L | ≥15 (1 pt) vs <15 × 109/L | >25 (1 pt) vs ≤25 × 109/L |
| Prior vascular events | Yes (1 pt) vs no | Yes (1 pt) vs no | |
| Anemia | <10 (2 pts) vs ≥10g/dL | ||
| Constitutional symptoms | Present* (1 pt) vs absent | ||
| Peripheral blood blasts | ≥1% (1 pt) vs <1% | ||
| Unfavorable karyotype | Present (1 pt) vs absent | ||
| RBC transfusion requirement | Present (1 pt) vs absent | ||
| Platelet count < 100 000 × 109 /L | Present (1 pt) vs absent | ||
| High risk | 3–4 points | 4 points | >4 points |
| Intermediate 2 risk | N/A | 3 points | 3–4 points |
| Intermediate 1 risk | 1–2 points | 1–2 points | 1–2 points |
| Low risk | 0 | 0 points | 0 points |
| . | ET . | PV . | PMF . |
|---|---|---|---|
| Thrombotic events | 10%–29%23 | 34%–39%23 | 7.2–13.2%65,66 |
| Bleeding events | 0.3%67 | 2.968 | – |
| Leukemic transformation | 2% at 15 y69,70 | 5.5% at 15 y27 | 6%–18%71 |
| Overall survival | 14.7 y70 | 6.5–24 y72,73 | 6–10 y28,74,75 |
| Risk algorithms | IPSET26 | Tefferi criteria27 | DIPSS PLUS2 |
| Age | ≥60 (2 pts) vs <60 | ≥67 (5 pts) 57–66 (2 pts) | ≥65 (1 pt) vs <65 |
| Leukocytes | ≥11 (1 pt) vs <11 × 109/L | ≥15 (1 pt) vs <15 × 109/L | >25 (1 pt) vs ≤25 × 109/L |
| Prior vascular events | Yes (1 pt) vs no | Yes (1 pt) vs no | |
| Anemia | <10 (2 pts) vs ≥10g/dL | ||
| Constitutional symptoms | Present* (1 pt) vs absent | ||
| Peripheral blood blasts | ≥1% (1 pt) vs <1% | ||
| Unfavorable karyotype | Present (1 pt) vs absent | ||
| RBC transfusion requirement | Present (1 pt) vs absent | ||
| Platelet count < 100 000 × 109 /L | Present (1 pt) vs absent | ||
| High risk | 3–4 points | 4 points | >4 points |
| Intermediate 2 risk | N/A | 3 points | 3–4 points |
| Intermediate 1 risk | 1–2 points | 1–2 points | 1–2 points |
| Low risk | 0 | 0 points | 0 points |
Constitutional symptoms were defined as weight loss over 6 months, night sweats, unexplained fever.29