OR and 95% CI for mtDNA copy number and B-NHL and major subtypes
| . | Logistic regression * . | ||||
|---|---|---|---|---|---|
| Q1 (6.7-23.6) . | Q2 (23.7-29.4) . | Q3 (29.5-36.2) . | Q4 (36.3-294.7) . | P trend . | |
| B-NHL | |||||
| n (case/control) | 112/107 | 77/105 | 85/104 | 144/102 | |
| Unadjusted OR (95% CI) | Ref. | 0.66 (0.43-1.02) | 0.81 (0.53-1.24) | 1.36 (0.91-2.04) | .04 |
| Adjusted OR (95% CI) | Ref. | 0.63 (0.40-0.99) | 0.79 (0.50-1.24) | 1.24 (0.81-1.92) | .13 |
| B-NHL without MM | |||||
| n | 82/84 | 55/72 | 61/81 | 111/72 | |
| Unadjusted OR (95% CI) | Ref. | 0.76 (0.46-1.25) | 0.79 (0.49-1.29) | 1.59 (1.01-2.50) | .03 |
| Adjusted OR (95% CI) | Ref. | 0.73 (0.43-1.22) | 0.79 (0.47-1.35) | 1.53 (0.93-2.52) | .05 |
| DLBCL | |||||
| n (case/control) | 21/117 | 12/117 | 6/118 | 21/117 | |
| Unadjusted OR (95% CI) | Ref. | 0.61 (0.30-1.24) | 0.32 (0.13-0.79) | 1.00 (0.55-1.83) | .76 |
| Adjusted OR (95% CI) | Ref. | 0.68 (0.32-1.48) | 0.22 (0.07-0.66) | 1.08 (0.54-2.14) | .75 |
| FL | |||||
| n (case/control) | 23/117 | 13/117 | 15/118 | 24/117 | |
| Unadjusted OR (95% CI) | Ref. | 0.61 (0.31-1.20) | 0.69 (0.36-1.32) | 1.04 (0.59-1.84) | .83 |
| Adjusted OR (95% CI) | Ref. | 0.55 (0.27-1.12) | 0.63 (0.32-1.25) | 0.94 (0.50-1.78) | .94 |
| CLL | |||||
| n (case/control) | 14/117 | 20/117 | 21/118 | 47/117 | |
| Unadjusted OR (95% CI) | Ref. | 1.37 (0.69-2.70) | 1.41 (0.72-2.78) | 2.68 (1.48-4.87) | .0004 |
| Adjusted OR (95% CI) | Ref. | 1.34 (0.66-2.70) | 1.44 (0.72-2.89) | 1.80 (1.48-5.28) | .001 |
| MM | |||||
| n (case/control) | 23/117 | 22/117 | 24/118 | 33/117 | |
| Unadjusted OR (95% CI) | Ref. | 0.78 (0.45-1.34) | 0.83 (0.48-1.42) | 1.08 (0.66-1.77) | .71 |
| Adjusted OR (95% CI) | Ref. | 0.80 (0.44-1.44) | 0.92 (0.52-1.63) | 1.15 (0.66-2.02) | .55 |
| Other B-NHL | |||||
| n (case/control) | 24/117 | 10/117 | 19/118 | 19/117 | |
| Unadjusted OR (95% CI) | Ref. | 0.39 (0.17-0.87) | 0.84 (0.46-1.55) | 0.85 (0.46-1.56) | .96 |
| Adjusted OR (95% CI) | Ref. | 0.41 (0.18-0.95) | 0.92 (0.48-1.76) | 1.00 (0.51-1.95) | .68 |
| . | Logistic regression * . | ||||
|---|---|---|---|---|---|
| Q1 (6.7-23.6) . | Q2 (23.7-29.4) . | Q3 (29.5-36.2) . | Q4 (36.3-294.7) . | P trend . | |
| B-NHL | |||||
| n (case/control) | 112/107 | 77/105 | 85/104 | 144/102 | |
| Unadjusted OR (95% CI) | Ref. | 0.66 (0.43-1.02) | 0.81 (0.53-1.24) | 1.36 (0.91-2.04) | .04 |
| Adjusted OR (95% CI) | Ref. | 0.63 (0.40-0.99) | 0.79 (0.50-1.24) | 1.24 (0.81-1.92) | .13 |
| B-NHL without MM | |||||
| n | 82/84 | 55/72 | 61/81 | 111/72 | |
| Unadjusted OR (95% CI) | Ref. | 0.76 (0.46-1.25) | 0.79 (0.49-1.29) | 1.59 (1.01-2.50) | .03 |
| Adjusted OR (95% CI) | Ref. | 0.73 (0.43-1.22) | 0.79 (0.47-1.35) | 1.53 (0.93-2.52) | .05 |
| DLBCL | |||||
| n (case/control) | 21/117 | 12/117 | 6/118 | 21/117 | |
| Unadjusted OR (95% CI) | Ref. | 0.61 (0.30-1.24) | 0.32 (0.13-0.79) | 1.00 (0.55-1.83) | .76 |
| Adjusted OR (95% CI) | Ref. | 0.68 (0.32-1.48) | 0.22 (0.07-0.66) | 1.08 (0.54-2.14) | .75 |
| FL | |||||
| n (case/control) | 23/117 | 13/117 | 15/118 | 24/117 | |
| Unadjusted OR (95% CI) | Ref. | 0.61 (0.31-1.20) | 0.69 (0.36-1.32) | 1.04 (0.59-1.84) | .83 |
| Adjusted OR (95% CI) | Ref. | 0.55 (0.27-1.12) | 0.63 (0.32-1.25) | 0.94 (0.50-1.78) | .94 |
| CLL | |||||
| n (case/control) | 14/117 | 20/117 | 21/118 | 47/117 | |
| Unadjusted OR (95% CI) | Ref. | 1.37 (0.69-2.70) | 1.41 (0.72-2.78) | 2.68 (1.48-4.87) | .0004 |
| Adjusted OR (95% CI) | Ref. | 1.34 (0.66-2.70) | 1.44 (0.72-2.89) | 1.80 (1.48-5.28) | .001 |
| MM | |||||
| n (case/control) | 23/117 | 22/117 | 24/118 | 33/117 | |
| Unadjusted OR (95% CI) | Ref. | 0.78 (0.45-1.34) | 0.83 (0.48-1.42) | 1.08 (0.66-1.77) | .71 |
| Adjusted OR (95% CI) | Ref. | 0.80 (0.44-1.44) | 0.92 (0.52-1.63) | 1.15 (0.66-2.02) | .55 |
| Other B-NHL | |||||
| n (case/control) | 24/117 | 10/117 | 19/118 | 19/117 | |
| Unadjusted OR (95% CI) | Ref. | 0.39 (0.17-0.87) | 0.84 (0.46-1.55) | 0.85 (0.46-1.56) | .96 |
| Adjusted OR (95% CI) | Ref. | 0.41 (0.18-0.95) | 0.92 (0.48-1.76) | 1.00 (0.51-1.95) | .68 |
The mtDNA copy number (per diploid genome) was categorized into quartiles (Q) based on the distribution among controls and modeled as categorical variable; Q number (minimum-maximum); P trend is the P value (2 sided) calculated by including the quartile number as a continuous variable.
Ref., reference.
Conditional logistic regression model adjusted for smoking status and education level was used for B-NHL, and an unconditional logistic regression model adjusted for age at recruitment, sex, country, smoking status, educational level, and plate number was used for subtype analyses.