GO analysis of transcripts deregulated in Cdk4R/R; Cdk6R/R BCR-ABL1–transformed cells
| Annotation clusters . | Description . | Representative genes upregulated . | Representative genes downregulated . |
|---|---|---|---|
| Apoptosis | GO:0043065, positive regulation of apoptosis; GO:0043067, regulation of programmed cell death; GO:0006917, induction of apoptosis; GO:0006916, anti-apoptosis; GO:0043066, negative regulation of apoptosis | AIPL1, ANK2, CDK5R1, CDKN2A, CHST11, DFFA, EAF2, FGFR3, IFIH1, IGF1, IL2RB, NOTCH2, NR4A1, PHLDA3, SPP1, TCF7, TGM2, TRAF2 | BBC3, BCL2A1D, BCL2A1C, BCL2L11, BCL3, BNIP3L, BTG2, CARD11, CD74, CDH1, CEBPB, CUL7, DDIT3, DMRT2, FAS, FCGR1, GCH1, IL18, IL2RA, LST1, LTB, MAPK8IP1, NLRC4, NUPR1, PROK2, RRM2B, SPHK1, TRP63, TSC22D3, UACA, VDR |
| Cell adhesion | GO:0007155, cell adhesion; PIR: cell adhesion; GO:0016337, cell–cell adhesion | ALCAM, APP, CD33, CD97, CDK5R1, CELSR1, ESAM, F11R, FBLN7, HSPG2, IBSP, ITGAM, L1CAM, LGALS3BP, NCAM2, NRP2, PCDH17, PCDHB16, PCDHB17, PCDHB20, PGM5, SPP1, SSPO | ARHGAP6, BCL2L11, CD36, CDH1, CLDN12, COL6A6, DSG2, FAT1, FNDC3A, ITGB4, LMO7, MEGF10, MYBPC2, NLGN2, PCDH11X, PVRL2, ROBO2, SELL, THY1, TRO |
| Cell projection and motion | GO:0007411, axon guidance; GO:0030030, cell projection organization; GO:0048858, cell projection morphogenesis; GO:0032989, cellular component morphogenesis; GO:0006928, cell motion | ALCAM, ANK3, APP, CDK5R1, DNAJA1, EFHD1, GM4776, ITGAM, L1CAM, NR2F1, NRP2, SEMA3A, SHROOM2, SOX6, TBR1, TNNT2, TNS3, VAV3, WWTR1 | ARID5B, BBS4, CHRNB2, EFNA5, EGR2, ETV1, FAT1, FEZF2, FGD3, ITGB4, LHX2, LPIN1, LST1, NEURL2, PDGFA, PLEKHG5, PTK2, RHOX5, ROBO2, ROBO3, RYK, TTC8, VANGL2 |
| Regulation of neurological processes | GO:0051969, regulation of transmission of nerve impulse; GO:0044057, regulation of system process; GO:0031644, regulation of neurological system process; GO:0019226, transmission of nerve impulse | APP, CELSR1, DLG2, IRX5, KCNMA1, MAOA, PCDHB16, SEMA3A, TNNT2, TRF | CHRNB2, COLQ, DRD5, EGR2, FKBP1B, GRIA2, GRIK5, GRM8, HEXA, LST1, LTB, NLGN2, P2RX3, PARK2, PROK2, PTK2 |
| Regulation of cytokine signaling | GO:0019955, cytokine binding; GO:0004896, cytokine receptor activity; GO:0019221, cytokine-mediated signaling pathway | IL1R1, IL1RAP, IL2RB | ACVR2B, CCR2, CD74, CXCR3, CXCR5, EBI3, IL1R2, IL12RB2, LIFR |
| Annotation clusters . | Description . | Representative genes upregulated . | Representative genes downregulated . |
|---|---|---|---|
| Apoptosis | GO:0043065, positive regulation of apoptosis; GO:0043067, regulation of programmed cell death; GO:0006917, induction of apoptosis; GO:0006916, anti-apoptosis; GO:0043066, negative regulation of apoptosis | AIPL1, ANK2, CDK5R1, CDKN2A, CHST11, DFFA, EAF2, FGFR3, IFIH1, IGF1, IL2RB, NOTCH2, NR4A1, PHLDA3, SPP1, TCF7, TGM2, TRAF2 | BBC3, BCL2A1D, BCL2A1C, BCL2L11, BCL3, BNIP3L, BTG2, CARD11, CD74, CDH1, CEBPB, CUL7, DDIT3, DMRT2, FAS, FCGR1, GCH1, IL18, IL2RA, LST1, LTB, MAPK8IP1, NLRC4, NUPR1, PROK2, RRM2B, SPHK1, TRP63, TSC22D3, UACA, VDR |
| Cell adhesion | GO:0007155, cell adhesion; PIR: cell adhesion; GO:0016337, cell–cell adhesion | ALCAM, APP, CD33, CD97, CDK5R1, CELSR1, ESAM, F11R, FBLN7, HSPG2, IBSP, ITGAM, L1CAM, LGALS3BP, NCAM2, NRP2, PCDH17, PCDHB16, PCDHB17, PCDHB20, PGM5, SPP1, SSPO | ARHGAP6, BCL2L11, CD36, CDH1, CLDN12, COL6A6, DSG2, FAT1, FNDC3A, ITGB4, LMO7, MEGF10, MYBPC2, NLGN2, PCDH11X, PVRL2, ROBO2, SELL, THY1, TRO |
| Cell projection and motion | GO:0007411, axon guidance; GO:0030030, cell projection organization; GO:0048858, cell projection morphogenesis; GO:0032989, cellular component morphogenesis; GO:0006928, cell motion | ALCAM, ANK3, APP, CDK5R1, DNAJA1, EFHD1, GM4776, ITGAM, L1CAM, NR2F1, NRP2, SEMA3A, SHROOM2, SOX6, TBR1, TNNT2, TNS3, VAV3, WWTR1 | ARID5B, BBS4, CHRNB2, EFNA5, EGR2, ETV1, FAT1, FEZF2, FGD3, ITGB4, LHX2, LPIN1, LST1, NEURL2, PDGFA, PLEKHG5, PTK2, RHOX5, ROBO2, ROBO3, RYK, TTC8, VANGL2 |
| Regulation of neurological processes | GO:0051969, regulation of transmission of nerve impulse; GO:0044057, regulation of system process; GO:0031644, regulation of neurological system process; GO:0019226, transmission of nerve impulse | APP, CELSR1, DLG2, IRX5, KCNMA1, MAOA, PCDHB16, SEMA3A, TNNT2, TRF | CHRNB2, COLQ, DRD5, EGR2, FKBP1B, GRIA2, GRIK5, GRM8, HEXA, LST1, LTB, NLGN2, P2RX3, PARK2, PROK2, PTK2 |
| Regulation of cytokine signaling | GO:0019955, cytokine binding; GO:0004896, cytokine receptor activity; GO:0019221, cytokine-mediated signaling pathway | IL1R1, IL1RAP, IL2RB | ACVR2B, CCR2, CD74, CXCR3, CXCR5, EBI3, IL1R2, IL12RB2, LIFR |
Most significantly deregulated functional pathways and their GO codes are shown first. See supplemental Table 2 for further details.