Prevalence and adjusted HRs for the associations between each of the 17 comorbidities included in the HCT-CI and risks of grades 3 to 4 acute GVHD among 2985 recipients of allogeneic HCT from 5 institutions
| Comorbidity category . | Prevalence, % . | HR* . |
|---|---|---|
| Peptic ulcer | 1.1 | 0.301 |
| Obesity | 8.2 | 0.974 |
| Diabetes | 4.5 | 1.028 |
| Heart valve disease | 1.5 | 1.047 |
| Prior malignancy | 5.9 | 1.081 |
| Renal | 0.7 | 1.089 |
| Psychiatric disorders | 11.4 | 1.181 |
| Cardiac | 5.4 | 1.186 |
| Cerebro-vascular disease | 1.4 | 1.289 |
| Severe pulmonary | 14.1 | 1.289 |
| Hepatic, mild | 15.5 | 1.313 |
| Moderate pulmonary | 26.7 | 1.352 |
| Arrhythmia | 3.0 | 1.440 |
| Moderate-severe hepatic | 4.4 | 1.463 |
| Rheumatologic | 3.0 | 1.488 |
| Inflammatory bowel disease | 1.0 | 1.606 |
| Infection | 5.6 | 1.637 |
| Comorbidity category . | Prevalence, % . | HR* . |
|---|---|---|
| Peptic ulcer | 1.1 | 0.301 |
| Obesity | 8.2 | 0.974 |
| Diabetes | 4.5 | 1.028 |
| Heart valve disease | 1.5 | 1.047 |
| Prior malignancy | 5.9 | 1.081 |
| Renal | 0.7 | 1.089 |
| Psychiatric disorders | 11.4 | 1.181 |
| Cardiac | 5.4 | 1.186 |
| Cerebro-vascular disease | 1.4 | 1.289 |
| Severe pulmonary | 14.1 | 1.289 |
| Hepatic, mild | 15.5 | 1.313 |
| Moderate pulmonary | 26.7 | 1.352 |
| Arrhythmia | 3.0 | 1.440 |
| Moderate-severe hepatic | 4.4 | 1.463 |
| Rheumatologic | 3.0 | 1.488 |
| Inflammatory bowel disease | 1.0 | 1.606 |
| Infection | 5.6 | 1.637 |
HRs were calculated for the association between each individual comorbidity and grades 3 to 4 acute GVHD, controlling for the presence of all coexisting comorbidities as well as for age, KPS score, and CMV serology results, diagnosis category, disease risk, and number of prior regimens, donor type, stem cell source, degree of conditioning intensity, inclusion of anti-thymocyte globulin in conditioning, and GVHD prophylaxis regimen.