Variables associated with low postthaw CD34+ cell viability
| Variable . | N units . | N with <75% CD34+ cell viability (%) . | Univariate analysis . | Multivariate analysis . | ||
|---|---|---|---|---|---|---|
| Odds ratio (95% CI) . | P . | Odds ratio (95% CI) . | P . | |||
| Cord blood bank Netcord-FACT accreditation | ||||||
| Yes | 350 | 15 (4%) | Reference | <.001 | Reference | .002 |
| No | 52 | 18 (35%) | 11.8 (5.5-25.6) | 4.9 (1.8-13.3) | ||
| Year of cryopreservation | ||||||
| 1997-2004 | 119 | 17 (14%) | 2.8 (1.4-5.7) | .005 | 1.47 (0.6-3.7) | .408 |
| 2005-2012 | 283 | 16 (6%) | Reference | Reference | ||
| Cryopreserved volume, mL | ||||||
| <24.5 | 14 | 5 (36%) | 20.1 (5.5-73.9) | <.001 | 8.8 (1.9-41.7) | <.001 |
| 24.5-26.0 | 298 | 8 (3%) | Reference | Reference | ||
| 26.1-29.9 | 45 | 7 (16%) | 6.7 (2.3-19.5) | 8.5 (2.6-28.0) | ||
| ≥30.0 | 45 | 13 (29%) | 14.7 (5.7-38.2) | 7.5 (2.5-22.0) | ||
| Method of processing | ||||||
| Manual | 187 | 24 (13%) | 3.4 (1.5-7.5) | .003 | 2.3 (0.8-6.5) | .131 |
| Automated and semiautomated* | 215 | 9 (4%) | Reference | Reference | ||
| Variable . | N units . | N with <75% CD34+ cell viability (%) . | Univariate analysis . | Multivariate analysis . | ||
|---|---|---|---|---|---|---|
| Odds ratio (95% CI) . | P . | Odds ratio (95% CI) . | P . | |||
| Cord blood bank Netcord-FACT accreditation | ||||||
| Yes | 350 | 15 (4%) | Reference | <.001 | Reference | .002 |
| No | 52 | 18 (35%) | 11.8 (5.5-25.6) | 4.9 (1.8-13.3) | ||
| Year of cryopreservation | ||||||
| 1997-2004 | 119 | 17 (14%) | 2.8 (1.4-5.7) | .005 | 1.47 (0.6-3.7) | .408 |
| 2005-2012 | 283 | 16 (6%) | Reference | Reference | ||
| Cryopreserved volume, mL | ||||||
| <24.5 | 14 | 5 (36%) | 20.1 (5.5-73.9) | <.001 | 8.8 (1.9-41.7) | <.001 |
| 24.5-26.0 | 298 | 8 (3%) | Reference | Reference | ||
| 26.1-29.9 | 45 | 7 (16%) | 6.7 (2.3-19.5) | 8.5 (2.6-28.0) | ||
| ≥30.0 | 45 | 13 (29%) | 14.7 (5.7-38.2) | 7.5 (2.5-22.0) | ||
| Method of processing | ||||||
| Manual | 187 | 24 (13%) | 3.4 (1.5-7.5) | .003 | 2.3 (0.8-6.5) | .131 |
| Automated and semiautomated* | 215 | 9 (4%) | Reference | Reference | ||
Specific techniques: AutoXpress Platform (AXP) (n = 82), Sepax (n = 102), Optipress (n = 27), Compomat (n = 3), and Biotrans Separator (n = 1).