Significant SNPs in meta-analysis and their statistics in individual cohorts
| Meta-Analysis of TSS 2,304 + GABC 940 (741 807 SNPs) . | TSS (N = 2304) . | GABC (n = 940) . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP . | Position* . | Region . | Gene . | Annotation . | P . | Dir . | A1 . | A2 . | MAF . | β (SE) . | P . | MAF . | β (SE) . | P . |
| rs4252129 | 161072895 | 6q26 | PLG | Coding-nonsyn | 1.9E-26 | − | T | C | 0.02 | −0.159 (0.014) | 2.2E-27 | 0.014 | −0.100 (0.035) | 5.1E-03 |
| rs1084651 | 161009807 | 6q26 | LPA | Intron | 1.6E-15 | − | A | G | 0.19 | −0.038 (0.005) | 2.5E-12 | 0.16 | −0.044 (0.011) | 1.2E-04 |
| rs783149 | 161008908 | 6q26 | LPA | 5′ upstream | 1.6E-14 | − | A | C | 0.19 | −0.037 (0.005) | 1.6E-11 | 0.17 | −0.042 (0.011) | 1.9E-04 |
| rs11751605 | 160883220 | 6q25.3 | LPA | Intron | 2.9E-12 | − | C | T | 0.17 | −0.042 (0.006) | 1.8E-13 | 0.13 | −0.018 (0.013) | .15 |
| rs1247513 | 161200369 | 6q26 | PLG | 3′ downstream | 2.8E-11 | − | T | C | 0.17 | −0.040 (0.006) | 5.8E-13 | 0.17 | −0.012 (0.011) | .27 |
| rs3120137 | 160691182 | 6q25.3 | SLC22A3 | Intron | 3.6E-10 | − | T | C | 0.17 | −0.036 (0.006) | 3.2E-10 | 0.13 | −0.022 (0.012) | .07 |
| rs4252137 | 161074440 | 6q26 | PLG | Intron | 1.9E-09 | − | A | G | 0.04 | −0.071 (0.011) | 4.8E-11 | 0.03 | −0.020 (0.024) | .39 |
| rs10412972 | 56846717 | 19q13.33 | SIGLEC14 | 5′ upstream | 1.1E-08 | ++ | A | G | 0.16 | 0.026 (0.006) | 8.1E-06 | 0.17 | 0.041 (0.011) | 2.7E-04 |
| rs11084102 | 56854528 | 19q13.33 | SIGLEC14 | 5′ upstream | 2.9E-08 | ++ | T | C | 0.14 | 0.026 (0.006) | 4.0E-05 | 0.15 | 0.047 (0.012) | 1.0E-04 |
| rs3127573 | 160601383 | 6q25.3 | SLC22A2 | 5′ upstream | 4.1E-08 | − | C | T | 0.13 | −0.034 (0.006) | 9.4E-08 | 0.11 | −0.025 (0.013) | 6.6E-02 |
| rs3127572 | 160602208 | 6q25.3 | SLC22A2 | 5′ upstream | 4.8E-08 | − | C | T | 0.13 | −0.033 (0.006) | 1.5E-07 | 0.12 | −0.025 (0.013) | 5.5E-02 |
| Meta-Analysis of TSS 2,304 + GABC 940 (741 807 SNPs) . | TSS (N = 2304) . | GABC (n = 940) . | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP . | Position* . | Region . | Gene . | Annotation . | P . | Dir . | A1 . | A2 . | MAF . | β (SE) . | P . | MAF . | β (SE) . | P . |
| rs4252129 | 161072895 | 6q26 | PLG | Coding-nonsyn | 1.9E-26 | − | T | C | 0.02 | −0.159 (0.014) | 2.2E-27 | 0.014 | −0.100 (0.035) | 5.1E-03 |
| rs1084651 | 161009807 | 6q26 | LPA | Intron | 1.6E-15 | − | A | G | 0.19 | −0.038 (0.005) | 2.5E-12 | 0.16 | −0.044 (0.011) | 1.2E-04 |
| rs783149 | 161008908 | 6q26 | LPA | 5′ upstream | 1.6E-14 | − | A | C | 0.19 | −0.037 (0.005) | 1.6E-11 | 0.17 | −0.042 (0.011) | 1.9E-04 |
| rs11751605 | 160883220 | 6q25.3 | LPA | Intron | 2.9E-12 | − | C | T | 0.17 | −0.042 (0.006) | 1.8E-13 | 0.13 | −0.018 (0.013) | .15 |
| rs1247513 | 161200369 | 6q26 | PLG | 3′ downstream | 2.8E-11 | − | T | C | 0.17 | −0.040 (0.006) | 5.8E-13 | 0.17 | −0.012 (0.011) | .27 |
| rs3120137 | 160691182 | 6q25.3 | SLC22A3 | Intron | 3.6E-10 | − | T | C | 0.17 | −0.036 (0.006) | 3.2E-10 | 0.13 | −0.022 (0.012) | .07 |
| rs4252137 | 161074440 | 6q26 | PLG | Intron | 1.9E-09 | − | A | G | 0.04 | −0.071 (0.011) | 4.8E-11 | 0.03 | −0.020 (0.024) | .39 |
| rs10412972 | 56846717 | 19q13.33 | SIGLEC14 | 5′ upstream | 1.1E-08 | ++ | A | G | 0.16 | 0.026 (0.006) | 8.1E-06 | 0.17 | 0.041 (0.011) | 2.7E-04 |
| rs11084102 | 56854528 | 19q13.33 | SIGLEC14 | 5′ upstream | 2.9E-08 | ++ | T | C | 0.14 | 0.026 (0.006) | 4.0E-05 | 0.15 | 0.047 (0.012) | 1.0E-04 |
| rs3127573 | 160601383 | 6q25.3 | SLC22A2 | 5′ upstream | 4.1E-08 | − | C | T | 0.13 | −0.034 (0.006) | 9.4E-08 | 0.11 | −0.025 (0.013) | 6.6E-02 |
| rs3127572 | 160602208 | 6q25.3 | SLC22A2 | 5′ upstream | 4.8E-08 | − | C | T | 0.13 | −0.033 (0.006) | 1.5E-07 | 0.12 | −0.025 (0.013) | 5.5E-02 |
A1, allele 1 (minor allele and tested allele); A2, allele 2 (major allele); Dir, direction of effect for the tested allele; SE, standard error.
Position uses NCBI Build 36 coordinates (UCSC hg18), which is used throughout the study.