Multivariate regression analysis including AML patients with FLT3/ITD and normal cytogenetics for CR, OS, and EFS
| Covariate . | CR . | OS . | EFS . | |||
|---|---|---|---|---|---|---|
| OR, 95% CI . | P value . | HR, 95% CI . | P value . | HR, 95% CI . | P value . | |
| NUP98-NSD1+/FLT3/ITD+* | 0.1 (0.04, 0.25) | <.001 | 2.05 (1.19, 3.53) | .01 | 2.34 (1.45, 3.78) | <.001 |
| NUP98-NSD1−/FLT3-ITD+* | 0.48 (0.28, 0.81) | .0058 | 1.39 (0.99 1.95) | .055 | 1.43 (1.07, 1.91) | .015 |
| NUP98-NSD1+/FLT3-ITD−* | 1.76 (0.2, 15.76) | .61 | 0.34 (0.05, 2.5) | .29 | 1.16 (0.42, 3.22) | .77 |
| Age (years) | 1.01 (0.98, 1.04) | .5 | 1.02 (1, 1.04) | .12 | 1.01 (0.99, 1.02) | .58 |
| Male gender (ref = female) | 1.19 (0.75, 1.91) | .46 | 0.8 (0.59, 1.06) | .12 | 0.97 (0.76, 1.25) | .84 |
| WBC | 0.86 (0.67, 1.1) | .22 | 1.18 (1.06, 1.31) | .0034 | 1.24 (1.12, 1.37) | <.001 |
| Marrow blasts (10%) | 1.08 (0.97, 1.2) | .14 | 1.07 (1, 1.15) | .061 | 1.03 (0.97, 1.09) | .37 |
| Platelets | 1.02 (0.91, 1.15) | .68 | 0.98 (0.84, 1.14) | .82 | 1.02 (1, 1.04) | .11 |
| NPM1+ (ref = NPM1−) | 2.69 (1.45, 5) | .0016 | 0.67 (0.47, 0.96) | .031 | 0.55 (0.4, 0.75) | <.001 |
| WT1+ (ref = WT+) | 0.59 (0.3,1.16) | .13 | 1.88 (1.24, 2.83) | .0028 | 1.63 (1.12, 2.37) | .0099 |
| SWOG (ref = COG) | 0.43 (0.13, 1.41) | .16 | 1.35 (0.65, 2.83) | .42 | 2.02 (1.04, 3.92) | .037 |
| Covariate . | CR . | OS . | EFS . | |||
|---|---|---|---|---|---|---|
| OR, 95% CI . | P value . | HR, 95% CI . | P value . | HR, 95% CI . | P value . | |
| NUP98-NSD1+/FLT3/ITD+* | 0.1 (0.04, 0.25) | <.001 | 2.05 (1.19, 3.53) | .01 | 2.34 (1.45, 3.78) | <.001 |
| NUP98-NSD1−/FLT3-ITD+* | 0.48 (0.28, 0.81) | .0058 | 1.39 (0.99 1.95) | .055 | 1.43 (1.07, 1.91) | .015 |
| NUP98-NSD1+/FLT3-ITD−* | 1.76 (0.2, 15.76) | .61 | 0.34 (0.05, 2.5) | .29 | 1.16 (0.42, 3.22) | .77 |
| Age (years) | 1.01 (0.98, 1.04) | .5 | 1.02 (1, 1.04) | .12 | 1.01 (0.99, 1.02) | .58 |
| Male gender (ref = female) | 1.19 (0.75, 1.91) | .46 | 0.8 (0.59, 1.06) | .12 | 0.97 (0.76, 1.25) | .84 |
| WBC | 0.86 (0.67, 1.1) | .22 | 1.18 (1.06, 1.31) | .0034 | 1.24 (1.12, 1.37) | <.001 |
| Marrow blasts (10%) | 1.08 (0.97, 1.2) | .14 | 1.07 (1, 1.15) | .061 | 1.03 (0.97, 1.09) | .37 |
| Platelets | 1.02 (0.91, 1.15) | .68 | 0.98 (0.84, 1.14) | .82 | 1.02 (1, 1.04) | .11 |
| NPM1+ (ref = NPM1−) | 2.69 (1.45, 5) | .0016 | 0.67 (0.47, 0.96) | .031 | 0.55 (0.4, 0.75) | <.001 |
| WT1+ (ref = WT+) | 0.59 (0.3,1.16) | .13 | 1.88 (1.24, 2.83) | .0028 | 1.63 (1.12, 2.37) | .0099 |
| SWOG (ref = COG) | 0.43 (0.13, 1.41) | .16 | 1.35 (0.65, 2.83) | .42 | 2.02 (1.04, 3.92) | .037 |
ref, reference.
Reference = NUP98-NSD1−/FLT3-ITD−.