Characteristics of patients with FLT3/ITD and CN-AML according to NUP98/NSD1 status
| Characteristics . | FLT3/ITD+ . | Normal cytogenetics . | ||||
|---|---|---|---|---|---|---|
| NUP98/NSD1− ( N = 216) . | NUP98/NSD1+ (N = 37) . | P value . | NUP98/NSD1− (N = 341) . | NUP98/NSD1+ (N = 26) . | P value . | |
| Age (years), median (range) | 15 (2-61) | 11 (3-51) | .003 | 15 (0-61) | 12 (1-51) | .022 |
| Study protocol, N (%) | .033 | .35 | ||||
| AAML03P1 | 21 (10) | 1 (3) | 28 (8) | 1 (4) | ||
| AAML0531 | 113 (52) | 20 (54) | 162 (48) | 15 (58) | ||
| CCG-2961 | 28 (13) | 11 (30) | 55 (16) | 6 (23) | ||
| S0106 | 54 (25) | 5 (14) | 96 (28) | 4 (15) | ||
| Male, N (%) | 117 (54) | 26 (70) | .075 | 177 (52) | 19 (73) | .042 |
| Cytogenetics, N (%) | .024 | NA | NA | NA | ||
| Favorable | 9 (4) | 0 (0) | ||||
| Intermediate | 133 (61) | 26 (70) | ||||
| Unfavorable | 25 (12) | 0 (0) | ||||
| Unknown risk | 15 (7) | 0 (0) | ||||
| Missing | 34 (16) | 11 (30) | ||||
| WBC × 109/L, median (range) | 44 (0-827) | 173 (3-860) | <.001 | 22 (0-827) | 79 (3-243) | <.001 |
| Marrow blast %, median (range) | 80 (3-100) | 86 (44-98) | .16 | 68 (0-100) | 85 (44-94) | .008 |
| Platelets × 109/L, median (range) | 48 (8-9300) | 85 (17-536) | <.001 | 52 (4-9300) | 72 (39-280) | .0075 |
| WT1+, N (%) | 32 (15) | 11 (30) | .031 | 26 (8) | 10 (38) | <.001 |
| NPM1+, N (%) | 63 (29) | 0 (0) | <.001 | 119 (35) | 0 (0) | <.001 |
| Characteristics . | FLT3/ITD+ . | Normal cytogenetics . | ||||
|---|---|---|---|---|---|---|
| NUP98/NSD1− ( N = 216) . | NUP98/NSD1+ (N = 37) . | P value . | NUP98/NSD1− (N = 341) . | NUP98/NSD1+ (N = 26) . | P value . | |
| Age (years), median (range) | 15 (2-61) | 11 (3-51) | .003 | 15 (0-61) | 12 (1-51) | .022 |
| Study protocol, N (%) | .033 | .35 | ||||
| AAML03P1 | 21 (10) | 1 (3) | 28 (8) | 1 (4) | ||
| AAML0531 | 113 (52) | 20 (54) | 162 (48) | 15 (58) | ||
| CCG-2961 | 28 (13) | 11 (30) | 55 (16) | 6 (23) | ||
| S0106 | 54 (25) | 5 (14) | 96 (28) | 4 (15) | ||
| Male, N (%) | 117 (54) | 26 (70) | .075 | 177 (52) | 19 (73) | .042 |
| Cytogenetics, N (%) | .024 | NA | NA | NA | ||
| Favorable | 9 (4) | 0 (0) | ||||
| Intermediate | 133 (61) | 26 (70) | ||||
| Unfavorable | 25 (12) | 0 (0) | ||||
| Unknown risk | 15 (7) | 0 (0) | ||||
| Missing | 34 (16) | 11 (30) | ||||
| WBC × 109/L, median (range) | 44 (0-827) | 173 (3-860) | <.001 | 22 (0-827) | 79 (3-243) | <.001 |
| Marrow blast %, median (range) | 80 (3-100) | 86 (44-98) | .16 | 68 (0-100) | 85 (44-94) | .008 |
| Platelets × 109/L, median (range) | 48 (8-9300) | 85 (17-536) | <.001 | 52 (4-9300) | 72 (39-280) | .0075 |
| WT1+, N (%) | 32 (15) | 11 (30) | .031 | 26 (8) | 10 (38) | <.001 |
| NPM1+, N (%) | 63 (29) | 0 (0) | <.001 | 119 (35) | 0 (0) | <.001 |
NA, not applicable.