Table 2

Multivariate analysis for aGVHD, relapse, and DFS

Variable*RR (95% CI)P
Grades 2 to 4 aGVHD   
 Patient age   
  >35 y old 0.744 (0.479-1.154) .187 
  <35 y old 
 Donor-patient gender   
  Female to male 1.618 (1.046-2.502) .031 
  Others 
 Donor-patient blood type relation   
  Mismatched 1.371 (0.918-2.047) .124 
  Matched 
 Number of CD34+ cells in stem cell   
  >5 × 106/kg 1.088 (0. 722-1.64) .687 
  <5 × 106/kg 
 Donor type   
  URD 3.525 (1.929-6.439) <.001 
  HRD 3.659 (1.997-6.705) <.001 
  MSD 1.0  
Relapse   
 Patient age   
  >35 y old 0.839 (0.464-1.519) .698 
  <35 y old 
 Underlying disease   
  Lymphoblastic malignancy 1.644 (0.931-2.904) .111 
  Myeloid malignancy 
 Risk classification   
  High risk 2.482 (1.333-4.624) .004 
  Standard risk 
 Disease status at HSCT   
  Advanced stage 1.814 (0.77-4.274) .262 
  CR 
 aGVHD   
  No 1.349 (0.69-2.638) .238 
  With aGVHD 
 cGVHD   
  No 2.685 (1.467-4.916) .001 
  With cGVHD 
 Donor type   
  MSD 1.343 (0.913-1.977) .044 
  URD 1.149 (0.791-1.67) .213 
  HRD 1.0  
High-risk leukemia relapse§   
 Patient age   
  >35 y old 0.677 (0.348-1.32) .268 
  <35 y old   
 Underlying disease   
  Lymphoblastic disease 1.285 (0.68-2.429) .52 
  No lymphoblastic   
 Disease status at HSCT   
  Advanced stage 1.791 (0.751-4.272) .163 
  CR   
 aGVHD   
  No 1.633 (0.781-3.415) .259 
  With aGVHD   
 cGVHD   
  No 2.772 (1.365-5.629) .005 
  With cGVHD   
 Donor type   
  MSD or URD 2.276 (1.056-4.902) .036 
  HRD 1.0  
DFS||   
 Patient age   
  >35 y old 1.268 (0.83-1.937) .272 
  <35 y old   
 Donor-patient gender   
  Female to male 1.207 (0.74-1.97) .451 
  Others   
 Donor-patient blood type relationship   
  Mismatched 0.939 (0.629-1.403) .76 
  Matched   
 Underlying disease   
  Lymphoblastic disease 1.701 (1.145-2.527) .009 
  No lymphoblastic   
 Cytogenetic risk   
  High risk 1.453 (0.917-2.304) .112 
  Standard risk   
 Disease status at HSCT   
  CR 1.381 (0.709-2.688) .342 
  Advanced stage   
 aGVHD   
  With aGVHD 1.625 (1.089-2.424) .017 
  No   
 cGVHD   
  No 2.875 (1.813-4.557) <.001 
  With cGVHD   
 Donor type   
  URD 1.34 (0.794-2.264) .273 
  HRD 1.193 (0.7-2.034) .516 
  MSD 1.0  
Variable*RR (95% CI)P
Grades 2 to 4 aGVHD   
 Patient age   
  >35 y old 0.744 (0.479-1.154) .187 
  <35 y old 
 Donor-patient gender   
  Female to male 1.618 (1.046-2.502) .031 
  Others 
 Donor-patient blood type relation   
  Mismatched 1.371 (0.918-2.047) .124 
  Matched 
 Number of CD34+ cells in stem cell   
  >5 × 106/kg 1.088 (0. 722-1.64) .687 
  <5 × 106/kg 
 Donor type   
  URD 3.525 (1.929-6.439) <.001 
  HRD 3.659 (1.997-6.705) <.001 
  MSD 1.0  
Relapse   
 Patient age   
  >35 y old 0.839 (0.464-1.519) .698 
  <35 y old 
 Underlying disease   
  Lymphoblastic malignancy 1.644 (0.931-2.904) .111 
  Myeloid malignancy 
 Risk classification   
  High risk 2.482 (1.333-4.624) .004 
  Standard risk 
 Disease status at HSCT   
  Advanced stage 1.814 (0.77-4.274) .262 
  CR 
 aGVHD   
  No 1.349 (0.69-2.638) .238 
  With aGVHD 
 cGVHD   
  No 2.685 (1.467-4.916) .001 
  With cGVHD 
 Donor type   
  MSD 1.343 (0.913-1.977) .044 
  URD 1.149 (0.791-1.67) .213 
  HRD 1.0  
High-risk leukemia relapse§   
 Patient age   
  >35 y old 0.677 (0.348-1.32) .268 
  <35 y old   
 Underlying disease   
  Lymphoblastic disease 1.285 (0.68-2.429) .52 
  No lymphoblastic   
 Disease status at HSCT   
  Advanced stage 1.791 (0.751-4.272) .163 
  CR   
 aGVHD   
  No 1.633 (0.781-3.415) .259 
  With aGVHD   
 cGVHD   
  No 2.772 (1.365-5.629) .005 
  With cGVHD   
 Donor type   
  MSD or URD 2.276 (1.056-4.902) .036 
  HRD 1.0  
DFS||   
 Patient age   
  >35 y old 1.268 (0.83-1.937) .272 
  <35 y old   
 Donor-patient gender   
  Female to male 1.207 (0.74-1.97) .451 
  Others   
 Donor-patient blood type relationship   
  Mismatched 0.939 (0.629-1.403) .76 
  Matched   
 Underlying disease   
  Lymphoblastic disease 1.701 (1.145-2.527) .009 
  No lymphoblastic   
 Cytogenetic risk   
  High risk 1.453 (0.917-2.304) .112 
  Standard risk   
 Disease status at HSCT   
  CR 1.381 (0.709-2.688) .342 
  Advanced stage   
 aGVHD   
  With aGVHD 1.625 (1.089-2.424) .017 
  No   
 cGVHD   
  No 2.875 (1.813-4.557) <.001 
  With cGVHD   
 Donor type   
  URD 1.34 (0.794-2.264) .273 
  HRD 1.193 (0.7-2.034) .516 
  MSD 1.0  

RR, relative risk.

*

The donor types and clinical factors included in the multivariate analysis were stated in the table.

Multivariate analysis was performed in 3 transplantation cohorts including 304 patients.

Multivariate analysis was performed in 3 transplantation cohorts including 304 patients.

§

Multivariate analysis was performed in 193 high-risk patients.

||

Multivariate analysis was performed in 3 transplantation cohorts including 305 patients.

or Create an Account

Close Modal
Close Modal