Extended HLA haplotype associations from factor analysis for Hispanics
| Variant . | OR . | Control frequency . | Lower 95% CI . | Upper 95% CI . | FDR P . | Factor analysis . |
|---|---|---|---|---|---|---|
| C*04:01∼B*44:03∼DRB4*01:01∼DRB1*07:01∼DQB1*02:01 | 4.18 | 0.007 | 1.48 | 11.78 | 3.93E-03 | Group 1 |
| DRB4*01:01∼DRB1*07:01∼DQB1*03:03 | 13.86 | 0.003 | 4.15 | 46.30 | 9.59E-09 | Group 2 |
| C*16:01∼B*45:01 | 3.47 | 0.009 | 1.16 | 10.37 | 1.70E-02 | Group 3 |
| B*35∼DRB4*01∼DRB1*07 | 5.76 | 0.006 | 2.07 | 16.03 | 1.27E-04 | Group 4 |
| A*24:02∼DRB1*07:01 | 4.27 | 0.008 | 1.65 | 11.08 | 1.29E-03 | Group 5 |
| C*07∼DRB5*01 | 2.25 | 0.040 | 1.04 | 4.86 | 2.96E-02 | Group 6 |
| C*07:04 | 5.60 | 0.006 | 1.67 | 18.74 | 5.71E-04 | Group 7 |
| Variant . | OR . | Control frequency . | Lower 95% CI . | Upper 95% CI . | FDR P . | Factor analysis . |
|---|---|---|---|---|---|---|
| C*04:01∼B*44:03∼DRB4*01:01∼DRB1*07:01∼DQB1*02:01 | 4.18 | 0.007 | 1.48 | 11.78 | 3.93E-03 | Group 1 |
| DRB4*01:01∼DRB1*07:01∼DQB1*03:03 | 13.86 | 0.003 | 4.15 | 46.30 | 9.59E-09 | Group 2 |
| C*16:01∼B*45:01 | 3.47 | 0.009 | 1.16 | 10.37 | 1.70E-02 | Group 3 |
| B*35∼DRB4*01∼DRB1*07 | 5.76 | 0.006 | 2.07 | 16.03 | 1.27E-04 | Group 4 |
| A*24:02∼DRB1*07:01 | 4.27 | 0.008 | 1.65 | 11.08 | 1.29E-03 | Group 5 |
| C*07∼DRB5*01 | 2.25 | 0.040 | 1.04 | 4.86 | 2.96E-02 | Group 6 |
| C*07:04 | 5.60 | 0.006 | 1.67 | 18.74 | 5.71E-04 | Group 7 |
The longest extended haplotype association for each factor analysis group is listed. When multiple haplotypes had the same number of loci within the same factor analysis group, the most significant association is provided. When no haplotypes were contained in a factor analysis group, the most significant allelic association is provided. Lower 95% CI and upper 95% CI indicate the ORs for the 95% CI. FDR P value is the significance after FDR correction for multiple testing. A complete listing of allele and haplotype associations for each factor analysis group with additional information on uncorrected P values, case frequencies, and interactions for age, geography, and gender is provided in supplemental Table 1.