Multivariate analysis: effect of HLA-DPB1 status (match, permissive, nonpermissive mismatch) on transplantation outcomes: 10/10 matching group
| Outcome . | HLA 10/10 match (permissive as baseline, N = 1881) . | HLA 9/10 match (permissive as baseline, N = 904) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Fully matched (N = 514) [RR (95% CI)] . | P value . | Nonpermissive (N = 600) [RR (95% CI)] . | P value . | Fully matched (N = 183) [RR (95% CI)] . | P value . | Nonpermissive (N = 317) [RR (95% CI)] . | P value . | |
| aGVHD II to IV | 0.7 (0.6-0.9) | <.001 | 1.1 (0.9-1.3) | NS | 0.9 (0.7-1.1) | NS | 1.0 (0.9-1.3) | NS |
| aGVHD III to IV | 0.7 (0.5-0.9) | .006 | 1.1 (0.9-1.4) | NS | 0.9 (0.6-1.3) | NS | 1.0 (0.7-1.3) | NS |
| cGVHD | 1.0 (0.8-1.1) | NS | 1.0 (0.9-1.2) | NS | 0.9 (0.7-1.2) | NS | 1.1 (0.9-1.4) | NS |
| Relapse | 1.4 (1.2-1.7) | <.001 | 1.0 (0.8-1.2) | NS | 1.0 (0.8-1.4) | NS | 1.1 (0.8-1.3) | NS |
| TRM | 1.0 (0.8-1.2) | NS | 1.4 (1.2-1.6) | <.001 | 0.8 (0.6-1.0) | NS | 1.0 (0.8-1.3) | NS |
| Treatment failure | 1.2 (1.1-1.4) | .003 | 1.1 (1.0-1.3) | .03 | 0.9 (0.7-1.1) | NS | 1.0 (0.9-1.2) | NS |
| Overall mortality | 1.1 (1.0-1.3) | NS | 1.2 (1.1-1.4) | .004 | 0.8 (0.7-1.0) | NS | 1.1 (0.9-1.3) | NS |
| Outcome . | HLA 10/10 match (permissive as baseline, N = 1881) . | HLA 9/10 match (permissive as baseline, N = 904) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Fully matched (N = 514) [RR (95% CI)] . | P value . | Nonpermissive (N = 600) [RR (95% CI)] . | P value . | Fully matched (N = 183) [RR (95% CI)] . | P value . | Nonpermissive (N = 317) [RR (95% CI)] . | P value . | |
| aGVHD II to IV | 0.7 (0.6-0.9) | <.001 | 1.1 (0.9-1.3) | NS | 0.9 (0.7-1.1) | NS | 1.0 (0.9-1.3) | NS |
| aGVHD III to IV | 0.7 (0.5-0.9) | .006 | 1.1 (0.9-1.4) | NS | 0.9 (0.6-1.3) | NS | 1.0 (0.7-1.3) | NS |
| cGVHD | 1.0 (0.8-1.1) | NS | 1.0 (0.9-1.2) | NS | 0.9 (0.7-1.2) | NS | 1.1 (0.9-1.4) | NS |
| Relapse | 1.4 (1.2-1.7) | <.001 | 1.0 (0.8-1.2) | NS | 1.0 (0.8-1.4) | NS | 1.1 (0.8-1.3) | NS |
| TRM | 1.0 (0.8-1.2) | NS | 1.4 (1.2-1.6) | <.001 | 0.8 (0.6-1.0) | NS | 1.0 (0.8-1.3) | NS |
| Treatment failure | 1.2 (1.1-1.4) | .003 | 1.1 (1.0-1.3) | .03 | 0.9 (0.7-1.1) | NS | 1.0 (0.9-1.2) | NS |
| Overall mortality | 1.1 (1.0-1.3) | NS | 1.2 (1.1-1.4) | .004 | 0.8 (0.7-1.0) | NS | 1.1 (0.9-1.3) | NS |
NS, not significant.