Multivariate analysis: effect of HLA-DPB1 status (match, permissive, nonpermissive mismatch) on transplantation outcomes: 8/8 matching group
| Outcome . | HLA 8/8 match (permissive as baseline, N = 2082) . | HLA 7/8 match (permissive as baseline, N = 854) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Fully matched (N = 546) [RR (95% CI)] . | P value . | Nonpermissive (N = 653) [RR (95% CI)] . | P value . | Fully matched (N = 169) [RR (95% CI)] . | P value . | Nonpermissive (N = 304) [RR (95% CI)] . | P value . | |
| aGVHD II to IV | 0.8 (0.6-0.9) | <.001 | 1.1 (1.0-1.3) | NS | 0.8 (0.6-1.0) | NS | 1.1 (0.9-1.3) | NS |
| aGVHD III to IV | 0.7 (0.5-0.9) | .007 | 1.1 (0.9-1.3) | NS | 0.8 (0.6-1.2) | NS | 1.1 (0.8-1.4) | NS |
| cGVHD | 0.9 (0.8-1.1) | NS | 1.0 (0.9-1.2) | NS | 1.1 (9.0-1.4) | NS | 1.2 (1.0-1.5) | NS |
| Relapse | 1.4 (1.2-1.6) | <.001 | 1.0 (0.9-1.2) | NS | 0.9 (0.7-1.2) | NS | 0.9 (0.7-1.1) | NS |
| TRM | 1.0 (0.8-1.1) | NS | 1.4 (1.2-1.6) | <.001 | 0.8 (0.6-1.1) | NS | 0.9 (0.8-1.2) | NS |
| Treatment failure | 1.2 (1.0-1.3) | .010 | 1.2 (1.0-1.3) | .007 | 0.9 (0.7-1.0) | NS | 0.9 (0.8-1.1) | NS |
| Overall mortality | 1.1 (0.9-1.2) | NS | 1.2 (1.1-1.4) | .002 | 0.8 (0.7-1.0) | NS | 1.0 (0.8-1.2) | NS |
| Outcome . | HLA 8/8 match (permissive as baseline, N = 2082) . | HLA 7/8 match (permissive as baseline, N = 854) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Fully matched (N = 546) [RR (95% CI)] . | P value . | Nonpermissive (N = 653) [RR (95% CI)] . | P value . | Fully matched (N = 169) [RR (95% CI)] . | P value . | Nonpermissive (N = 304) [RR (95% CI)] . | P value . | |
| aGVHD II to IV | 0.8 (0.6-0.9) | <.001 | 1.1 (1.0-1.3) | NS | 0.8 (0.6-1.0) | NS | 1.1 (0.9-1.3) | NS |
| aGVHD III to IV | 0.7 (0.5-0.9) | .007 | 1.1 (0.9-1.3) | NS | 0.8 (0.6-1.2) | NS | 1.1 (0.8-1.4) | NS |
| cGVHD | 0.9 (0.8-1.1) | NS | 1.0 (0.9-1.2) | NS | 1.1 (9.0-1.4) | NS | 1.2 (1.0-1.5) | NS |
| Relapse | 1.4 (1.2-1.6) | <.001 | 1.0 (0.9-1.2) | NS | 0.9 (0.7-1.2) | NS | 0.9 (0.7-1.1) | NS |
| TRM | 1.0 (0.8-1.1) | NS | 1.4 (1.2-1.6) | <.001 | 0.8 (0.6-1.1) | NS | 0.9 (0.8-1.2) | NS |
| Treatment failure | 1.2 (1.0-1.3) | .010 | 1.2 (1.0-1.3) | .007 | 0.9 (0.7-1.0) | NS | 0.9 (0.8-1.1) | NS |
| Overall mortality | 1.1 (0.9-1.2) | NS | 1.2 (1.1-1.4) | .002 | 0.8 (0.7-1.0) | NS | 1.0 (0.8-1.2) | NS |
NS, not significant.