Main multivariate analyses: effect of HLA mismatch and other non-HLA variables on overall mortality
| Variable/category . | N . | RR . | 95% CI . | P value . |
|---|---|---|---|---|
| Matching for Early disease | ||||
| 8/8 | 2528 | 1 | <.001 | |
| 7/8 | 882 | 1.3 | 1.1-1.4 | <.001 |
| 6/8 | 157 | 2.0 | 1.7-2.5 | <.001 |
| Matching for Intermediate disease | ||||
| 8/8 | 1477 | 1 | <.001 | |
| 7/8 | 667 | 1.4 | 1.2-1.6 | <.001 |
| 6/8 | 180 | 1.6 | 1.3-2.0 | <.001 |
| Matching for Advanced disease | ||||
| 8/8 | 1442 | 1 | .007 | |
| 7/8 | 522 | 1.2 | 1.1-1.3 | .002 |
| 6/8 | 146 | 1.1 | 0.9-1.4 | NS |
| Graft type (≤12 mo) | ||||
| BM | 3497 | 1 | ||
| PB | 4504 | 0.9 | 0.9-1.0 | NS |
| Graft type (>12 mo) | ||||
| BM | 1873 | 1 | ||
| PB | 2314 | 1.3 | 1.2-1.5 | <.001 |
| Year of transplant (≤10 mo) | ||||
| 1999-2002 | 1570 | 1 | <.001 | |
| 2003-2006 | 2524 | 0.7 | 0.7-0.8 | <.001 |
| 2007-2011 | 3907 | 0.6 | 0.5-0.7 | <.001 |
| Year of transplant (>10 mo) | ||||
| 1999-2002 | 779 | 1 | NS | |
| 2003-2006 | 1478 | 1.0 | 0.9-1.2 | NS |
| 2007-2011 | 2325 | 1.1 | 1.0-1.3 | NS |
| Recipient age (years) | ||||
| <10 | 715 | 1 | ||
| 10-19 | 1054 | 1.4 | 1.2-1.6 | <.001 |
| 20-29 | 1304 | 1.5 | 1.3-1.8 | <.001 |
| 30-39 | 1337 | 1.7 | 1.4-1.9 | <.001 |
| 40-49 | 1655 | 1.8 | 1.6-2.1 | <.001 |
| 50-59 | 1437 | 2.2 | 1.9-2.5 | <.001 |
| >60 | 499 | 2.3 | 2.0-2.8 | <.001 |
| Race | ||||
| White | 7050 | 1 | ||
| African American | 381 | 1.3 | 1.2-1.5 | <.001 |
| Other | 446 | 1.0 | 0.9-1.2 | NS |
| Missing | 124 | 0.9 | 0.7-1.2 | NS |
| KPS | ||||
| 90-100% | 5362 | 1 | ||
| <90% | 2050 | 1.3 | 1.3-1.4 | <.001 |
| Missing | 589 | 1.0 | 0.9-1.1 | NS |
| Disease | ||||
| AML | 3809 | 1 | ||
| ALL | 2301 | 1.1 | 1.0-1.2 | NS |
| CML | 1090 | 0.9 | 0.8-0.9 | .003 |
| MDS | 801 | 0.8 | 0.7-0.9 | <.001 |
| CMV match (donor/recipient) | ||||
| −/− | 2431 | 1 | ||
| −/+ | 2661 | 1.2 | 1.1-1.3 | <.001 |
| +/− | 999 | 1.1 | 1.0-1.2 | NS |
| +/+ | 1805 | 1.1 | 1.0-1.2 | NS |
| Missing | 105 | 1.1 | 0.9-1.5 | NS |
| ABO match (donor/recipient) | ||||
| Matched | 2948 | 1 | ||
| Minor mismatch | 1683 | 1.1 | 1.0-1.2 | .002 |
| Major mismatch | 1665 | 1.1 | 1.0-1.2 | .003 |
| Bidirectional mismatch | 535 | 1.1 | 0.9-1.2 | NS |
| Missing | 1170 | 1.0 | 0.9-1.2 | NS |
| TBI | ||||
| Yes | 4501 | 1 | ||
| No | 3431 | 0.9 | 0.8-1.0 | .002 |
| Missing | 69 | 1.0 | 0.7-1.4 | NS |
| GVHD prophylaxis | ||||
| FK506 + (MTX/MMF/steroids) + other | 4480 | 1 | ||
| FK506 + other | 416 | 1.0 | 0.8-1.1 | NS |
| CsA + MTX + other | 2096 | 1.0 | 0.9-1.1 | NS |
| CsA + other (no MTX) | 243 | 1.5 | 1.3-1.7 | <.001 |
| T-cell depletion | 514 | 1.0 | 0.9-1.1 | NS |
| Other | 252 | 1.1 | 0.9-1.3 | NS |
| Variable/category . | N . | RR . | 95% CI . | P value . |
|---|---|---|---|---|
| Matching for Early disease | ||||
| 8/8 | 2528 | 1 | <.001 | |
| 7/8 | 882 | 1.3 | 1.1-1.4 | <.001 |
| 6/8 | 157 | 2.0 | 1.7-2.5 | <.001 |
| Matching for Intermediate disease | ||||
| 8/8 | 1477 | 1 | <.001 | |
| 7/8 | 667 | 1.4 | 1.2-1.6 | <.001 |
| 6/8 | 180 | 1.6 | 1.3-2.0 | <.001 |
| Matching for Advanced disease | ||||
| 8/8 | 1442 | 1 | .007 | |
| 7/8 | 522 | 1.2 | 1.1-1.3 | .002 |
| 6/8 | 146 | 1.1 | 0.9-1.4 | NS |
| Graft type (≤12 mo) | ||||
| BM | 3497 | 1 | ||
| PB | 4504 | 0.9 | 0.9-1.0 | NS |
| Graft type (>12 mo) | ||||
| BM | 1873 | 1 | ||
| PB | 2314 | 1.3 | 1.2-1.5 | <.001 |
| Year of transplant (≤10 mo) | ||||
| 1999-2002 | 1570 | 1 | <.001 | |
| 2003-2006 | 2524 | 0.7 | 0.7-0.8 | <.001 |
| 2007-2011 | 3907 | 0.6 | 0.5-0.7 | <.001 |
| Year of transplant (>10 mo) | ||||
| 1999-2002 | 779 | 1 | NS | |
| 2003-2006 | 1478 | 1.0 | 0.9-1.2 | NS |
| 2007-2011 | 2325 | 1.1 | 1.0-1.3 | NS |
| Recipient age (years) | ||||
| <10 | 715 | 1 | ||
| 10-19 | 1054 | 1.4 | 1.2-1.6 | <.001 |
| 20-29 | 1304 | 1.5 | 1.3-1.8 | <.001 |
| 30-39 | 1337 | 1.7 | 1.4-1.9 | <.001 |
| 40-49 | 1655 | 1.8 | 1.6-2.1 | <.001 |
| 50-59 | 1437 | 2.2 | 1.9-2.5 | <.001 |
| >60 | 499 | 2.3 | 2.0-2.8 | <.001 |
| Race | ||||
| White | 7050 | 1 | ||
| African American | 381 | 1.3 | 1.2-1.5 | <.001 |
| Other | 446 | 1.0 | 0.9-1.2 | NS |
| Missing | 124 | 0.9 | 0.7-1.2 | NS |
| KPS | ||||
| 90-100% | 5362 | 1 | ||
| <90% | 2050 | 1.3 | 1.3-1.4 | <.001 |
| Missing | 589 | 1.0 | 0.9-1.1 | NS |
| Disease | ||||
| AML | 3809 | 1 | ||
| ALL | 2301 | 1.1 | 1.0-1.2 | NS |
| CML | 1090 | 0.9 | 0.8-0.9 | .003 |
| MDS | 801 | 0.8 | 0.7-0.9 | <.001 |
| CMV match (donor/recipient) | ||||
| −/− | 2431 | 1 | ||
| −/+ | 2661 | 1.2 | 1.1-1.3 | <.001 |
| +/− | 999 | 1.1 | 1.0-1.2 | NS |
| +/+ | 1805 | 1.1 | 1.0-1.2 | NS |
| Missing | 105 | 1.1 | 0.9-1.5 | NS |
| ABO match (donor/recipient) | ||||
| Matched | 2948 | 1 | ||
| Minor mismatch | 1683 | 1.1 | 1.0-1.2 | .002 |
| Major mismatch | 1665 | 1.1 | 1.0-1.2 | .003 |
| Bidirectional mismatch | 535 | 1.1 | 0.9-1.2 | NS |
| Missing | 1170 | 1.0 | 0.9-1.2 | NS |
| TBI | ||||
| Yes | 4501 | 1 | ||
| No | 3431 | 0.9 | 0.8-1.0 | .002 |
| Missing | 69 | 1.0 | 0.7-1.4 | NS |
| GVHD prophylaxis | ||||
| FK506 + (MTX/MMF/steroids) + other | 4480 | 1 | ||
| FK506 + other | 416 | 1.0 | 0.8-1.1 | NS |
| CsA + MTX + other | 2096 | 1.0 | 0.9-1.1 | NS |
| CsA + other (no MTX) | 243 | 1.5 | 1.3-1.7 | <.001 |
| T-cell depletion | 514 | 1.0 | 0.9-1.1 | NS |
| Other | 252 | 1.1 | 0.9-1.3 | NS |
Non-HLA variables that had significant association with overall mortality. Such variables with significant association with other studied outcomes are not presented in the above table, but rather are outlined here: grade II to IV acute GVHD—disease, graft type, donor age, gender mismatch, GVHD prophylaxis, and in vivo T-cell depletion; chronic GVHD—year of HCT, recipient age, disease, graft type, gender mismatch, GVHD prophylaxis, and in vivo T-cell depletion; relapse—KPS, disease, disease status, GVHD prophylaxis; TRM—graft type, year of HCT, recipient age, race, KPS, disease, disease status, donor age, CMV matching, ABO matching, and TBI vs non–TBI-containing regimens.