Main multivariate analyses: effect of HLA mismatch on transplantation outcomes
| Outcome (8/8 baseline, N=5447) . | 7/8 (N = 2071) RR (95% CI) . | P value . | 6/8 (N = 483) RR (95% CI) . | P value . | 7/8 vs 6/8 RR (95% CI) . |
|---|---|---|---|---|---|
| Acute GVHD II to IV | 1.2 (1.1-1.4) | <.0001 | 1.4 (1.2-1.5) | .0001 | NS |
| Acute GVHD III to IV | 1.6 (1.4-1.8) | <.0001 | 1.8 (1.5-2.2) | <.0001 | NS |
| Chronic GVHD | 1.2 (1.1-1.3) | <.0001 | 1.2 (1.0-1.4) | NS | NS |
| Relapse | NS | NS | |||
| TRM | 1.5 (1.3-1.6) | <.0001 | 1.8 (1.6-2.1) | <.0001 | 0.8 (0.7-0.93), 0.003 |
| Treatment failure - early | 1.3 (1.1-1.4) | <.0001 | 1.9 (1.6-2.3) | <.0001 | 0.7 (0.5-0.8), <0.0001 |
| Treatment failure – intermediate | 1.3 (1.2-1.5) | <.0001 | 1.5 (1.2-1.8) | <.0001 | NS |
| Treatment failure – advanced | 1.2 (1.0-1.3) | .01 | 1.1 (0.9-1.3) | NS | NS |
| Overall mortality – early | 1.3 (1.1-1.4) | <.0001 | 2.0 (1.7-2.5) | <.0001 | 0.62 (0.5-0.8), <0.0001 |
| Overall mortality – intermediate | 1.4 (1.2-1.6) | <.0001 | 1.6 (1.3-2.0) | <.0001 | NS |
| Overall mortality - advanced | 1.2 (1.1-1.3) | .002 | 1.1 (0.9-1.4) | NS | NS |
| Outcome (8/8 baseline, N=5447) . | 7/8 (N = 2071) RR (95% CI) . | P value . | 6/8 (N = 483) RR (95% CI) . | P value . | 7/8 vs 6/8 RR (95% CI) . |
|---|---|---|---|---|---|
| Acute GVHD II to IV | 1.2 (1.1-1.4) | <.0001 | 1.4 (1.2-1.5) | .0001 | NS |
| Acute GVHD III to IV | 1.6 (1.4-1.8) | <.0001 | 1.8 (1.5-2.2) | <.0001 | NS |
| Chronic GVHD | 1.2 (1.1-1.3) | <.0001 | 1.2 (1.0-1.4) | NS | NS |
| Relapse | NS | NS | |||
| TRM | 1.5 (1.3-1.6) | <.0001 | 1.8 (1.6-2.1) | <.0001 | 0.8 (0.7-0.93), 0.003 |
| Treatment failure - early | 1.3 (1.1-1.4) | <.0001 | 1.9 (1.6-2.3) | <.0001 | 0.7 (0.5-0.8), <0.0001 |
| Treatment failure – intermediate | 1.3 (1.2-1.5) | <.0001 | 1.5 (1.2-1.8) | <.0001 | NS |
| Treatment failure – advanced | 1.2 (1.0-1.3) | .01 | 1.1 (0.9-1.3) | NS | NS |
| Overall mortality – early | 1.3 (1.1-1.4) | <.0001 | 2.0 (1.7-2.5) | <.0001 | 0.62 (0.5-0.8), <0.0001 |
| Overall mortality – intermediate | 1.4 (1.2-1.6) | <.0001 | 1.6 (1.3-2.0) | <.0001 | NS |
| Overall mortality - advanced | 1.2 (1.1-1.3) | .002 | 1.1 (0.9-1.4) | NS | NS |
NS, not significant.