Table 2 Pharmacokinetic parameters of... | American Society of Hematology

Table 2

Pharmacokinetic parameters of afuresertib

Dose (mg)	No. of patients	C_max (ng/mL)		AUC_0-24 (ng•h/mL)		Accumulation ratio		C₀ (ng/mL)
Dose (mg)	No. of patients	Single dose	Repeat dose	Single dose	Repeat dose	Single dose	Repeat dose	Day 8	Day 15
25	2	26.5, 39.7	57.3, 79.8	294, 413	891, 1393	—	3.0, 3.4	30.5, 36.7	42.3, 48.0
75	2	101, 112	244, 252	1003, 1139	3022, 3193	—	3.2, 2.7	93.8, 155	96.9, 131
100	8	244 ± 158	554 ± 198	2366 ± 992	6782 ± 2004	—	3.3 ± 1.6	249 ± 107	261 ± 162
125	8	175 ± 82.7	531 ± 288	2378 ± 1004	7405 ± 3584	—	2.9 ± 0.7	259 ± 105	342 ± 172
150	6	350 ± 162	949 ± 348	4379 ± 1288	13425 ± 3953	—	3.0 ± 1.3	624 ± 345	822 ± 576

Dose (mg)	No. of patients	C_max (ng/mL)		AUC_0-24 (ng•h/mL)		Accumulation ratio		C₀ (ng/mL)
Dose (mg)	No. of patients	Single dose	Repeat dose	Single dose	Repeat dose	Single dose	Repeat dose	Day 8	Day 15
25	2	26.5, 39.7	57.3, 79.8	294, 413	891, 1393	—	3.0, 3.4	30.5, 36.7	42.3, 48.0
75	2	101, 112	244, 252	1003, 1139	3022, 3193	—	3.2, 2.7	93.8, 155	96.9, 131
100	8	244 ± 158	554 ± 198	2366 ± 992	6782 ± 2004	—	3.3 ± 1.6	249 ± 107	261 ± 162
125	8	175 ± 82.7	531 ± 288	2378 ± 1004	7405 ± 3584	—	2.9 ± 0.7	259 ± 105	342 ± 172
150	6	350 ± 162	949 ± 348	4379 ± 1288	13425 ± 3953	—	3.0 ± 1.3	624 ± 345	822 ± 576

Single- and repeat-dose data are presented as mean ± standard deviation except for 25- and 75-mg doses, which are presented as individual values; the number of patients with repeat doses is the same as that for single dose, except for 125 mg (n = 6) and 150 mg (n = 5).

AUC_0-24, area under the plasma concentration-time curve from time 0 to 24 hours; C_max, maximum plasma concentration; C₀, predose concentration on day 8 and day 15.

View Large