Predictors of VTE in all first-degree relatives
| Characteristic . | Univariable (each variable separately) . | Multivariable (only variables with P < .1 in the univariable model) . | ||
|---|---|---|---|---|
| Odds ratio . | P . | Odds ratio . | P . | |
| Index case | ||||
| Unprovoked vs provoked * | 2.50 (1.54-4.00) | <.001 | 2.38 (1.43-3.85) | .001 |
| FVL and/or PGM vs neither | 1.70 (1.16-2.50) | .007 | 1.34 (0.89-2.01) | .16 |
| Age at diagnosis (per year)† | 0.98 (0.97-0.99) | <.001 | 0.97 (0.96-0.99) | <.001 |
| Female vs male | 0.96 (0.67-1.38) | .81 | ||
| Pulmonary embolism vs deep vein thrombosis | 0.91 (0.63-1.31) | .61 | ||
| First-degree relatives | ||||
| Female vs male | 1.62 (1.12-2.35) | .011 | 1.37 (0.94-2.02) | .11 |
| Age (per year) | 1.04 (1.03-1.05) | <.001 | 1.06 (1.04-1.07) | <.001 |
| Relationship to index case | <.001 | .33 | ||
| Parent | 4.76 (2.58-8.76) | <.001 | 0.59 (0.18-1.90) | .37 |
| Sibling | 3.37 (1.81-6.16) | <.001 | 0.94 (0.43-2.10) | .89 |
| Child | Reference | Reference | ||
| Dead vs alive | 0.69 (0.45-1.06) | .09 | 0.44 (0.28-0.72) | .001 |
| Characteristic . | Univariable (each variable separately) . | Multivariable (only variables with P < .1 in the univariable model) . | ||
|---|---|---|---|---|
| Odds ratio . | P . | Odds ratio . | P . | |
| Index case | ||||
| Unprovoked vs provoked * | 2.50 (1.54-4.00) | <.001 | 2.38 (1.43-3.85) | .001 |
| FVL and/or PGM vs neither | 1.70 (1.16-2.50) | .007 | 1.34 (0.89-2.01) | .16 |
| Age at diagnosis (per year)† | 0.98 (0.97-0.99) | <.001 | 0.97 (0.96-0.99) | <.001 |
| Female vs male | 0.96 (0.67-1.38) | .81 | ||
| Pulmonary embolism vs deep vein thrombosis | 0.91 (0.63-1.31) | .61 | ||
| First-degree relatives | ||||
| Female vs male | 1.62 (1.12-2.35) | .011 | 1.37 (0.94-2.02) | .11 |
| Age (per year) | 1.04 (1.03-1.05) | <.001 | 1.06 (1.04-1.07) | <.001 |
| Relationship to index case | <.001 | .33 | ||
| Parent | 4.76 (2.58-8.76) | <.001 | 0.59 (0.18-1.90) | .37 |
| Sibling | 3.37 (1.81-6.16) | <.001 | 0.94 (0.43-2.10) | .89 |
| Child | Reference | Reference | ||
| Dead vs alive | 0.69 (0.45-1.06) | .09 | 0.44 (0.28-0.72) | .001 |
CI, confidence interval; DVT, deep vein thrombosis; FVL, factor V Leiden; PE, pulmonary embolism; PGM, prothrombin 20210A gene variant; VTE, venous thromboembolism.
For provoked vs unprovoked: univariable odds ratio, 0.40 (95% CI, 0.25-0.65); multivariable odds ratio, 0.42 (95% CI, 0.26-0.70).
When age was divided into quartiles with the fourth quartile (>72 years) as the reference, the adjusted odds ratio for VTE was 1.40 (95% CI, 0.81-2.41; P = .22) in the third quartile (62-72 years), 1.47 (95% CI, 0.83-2.60; P = .18) in the second quartile (48-61 years), and 3.49 (95% CI, 1.98-6.14; P < .001) in the first quartile (<47 years).