Response to treatment and by patient characteristics
| Patient subgroup . | n . | Response category, n (%) . | ||||
|---|---|---|---|---|---|---|
| ≥PR . | ≥VGPR . | ≥nCR . | ≥CR . | sCR . | ||
| Overall | 55 | 52 (95) | 39 (71) | 27 (49) | 18 (33) | 11 (20) |
| Age | ||||||
| <75 years | 41 | 38 (93) | 29 (71) | 22 (54) | 13 (32) | 8 (20) |
| ≥75 years | 14 | 14 (100) | 10 (71) | 5 (36) | 5 (36) | 3 (21) |
| ISS stage | ||||||
| I | 16 | 15 (94) | 10 (63) | 8 (50) | 5 (31) | 3 (19) |
| II | 18 | 18 (100) | 14 (78) | 12 (67) | 8 (44) | 6 (33) |
| III | 21 | 20 (95) | 15 (71) | 7 (33) | 5 (24) | 2 (10) |
| Chromosomal abnormalities | ||||||
| Normal/favorable | 31 | 29 (94) | 23 (74) | 17 (55) | 10 (32) | 6 (19) |
| Unfavorable* | 17 | 16 (94) | 12 (71) | 7 (41) | 5 (29) | 3 (18) |
| Treatment duration | ||||||
| Second cycle | 53 | 40 (75) | 16 (30) | 3 (6) | — | — |
| Fourth cycle | 46 | 41 (89) | 26 (57) | 11 (24) | — | 1 (2) |
| Sixth cycle | 43 | 43 (100) | 34 (79) | 13 (30) | — | 4 (9) |
| Ninth cycle | 43 | 43 (100) | 33 (77) | 20 (47) | — | 10 (23) |
| Patient subgroup . | n . | Response category, n (%) . | ||||
|---|---|---|---|---|---|---|
| ≥PR . | ≥VGPR . | ≥nCR . | ≥CR . | sCR . | ||
| Overall | 55 | 52 (95) | 39 (71) | 27 (49) | 18 (33) | 11 (20) |
| Age | ||||||
| <75 years | 41 | 38 (93) | 29 (71) | 22 (54) | 13 (32) | 8 (20) |
| ≥75 years | 14 | 14 (100) | 10 (71) | 5 (36) | 5 (36) | 3 (21) |
| ISS stage | ||||||
| I | 16 | 15 (94) | 10 (63) | 8 (50) | 5 (31) | 3 (19) |
| II | 18 | 18 (100) | 14 (78) | 12 (67) | 8 (44) | 6 (33) |
| III | 21 | 20 (95) | 15 (71) | 7 (33) | 5 (24) | 2 (10) |
| Chromosomal abnormalities | ||||||
| Normal/favorable | 31 | 29 (94) | 23 (74) | 17 (55) | 10 (32) | 6 (19) |
| Unfavorable* | 17 | 16 (94) | 12 (71) | 7 (41) | 5 (29) | 3 (18) |
| Treatment duration | ||||||
| Second cycle | 53 | 40 (75) | 16 (30) | 3 (6) | — | — |
| Fourth cycle | 46 | 41 (89) | 26 (57) | 11 (24) | — | 1 (2) |
| Sixth cycle | 43 | 43 (100) | 34 (79) | 13 (30) | — | 4 (9) |
| Ninth cycle | 43 | 43 (100) | 33 (77) | 20 (47) | — | 10 (23) |
Presence of t(4;14) or t(14;16) or deletion chromosome 17.