Disease and patient characteristics as risk factors for OS and PFS in the entire cohort
| Factor . | OS (n = 685) . | PFS (n = 654) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariable . | Multivariable . | Univariable . | Multivariable . | |||||
| . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| Age | 1.040 (1.033-1.046) | <.001 | 1.038 (1.030-1.046) | <.001 | 1.030 (1.024-1.036) | <.001 | 1.029 (1.021-1.036) | <.001 |
| Male gender | 1.16 (0.97-1.37) | .098 | 1.28 (1.06-1.55) | .011 | 1.15 (0.97-1.36) | .101 | 1.26 (1.05-1.51) | .014 |
| B symptoms | 1.65 (1.38-1.97) | <.001 | 1.31 (1.07-1.60) | .010 | 1.61 (1.35-1.92) | <.001 | 1.38 (1.13-1.69) | .002 |
| Ann Arbor III-IV | 2.00 (1.64-2.42) | <.001 | 1.41 (1.12-1.77) | .003 | 2.00 (1.65-2.42) | <.001 | 1.48 (1.18-1.85) | .003 |
| BM | 1.51 (1.24-1.85) | <.001 | — | — | 1.48 (1.22-1.79) | <.001 | — | — |
| Extranodal involvement >1 | 1.85 (1.48-2.31) | <.001 | 1.47 (1.14-1.88) | .003 | 1.81 (1.45-2.25) | <.001 | 1.55 (1.22-1.98) | <.001 |
| WHO PS >1 | 2.48 (2.09-2.94) | <.001 | 1.65 (1.34-2.02) | <.001 | 2.26 (1.91-2.68) | <.001 | 1.68 (1.37-2.04) | <.001 |
| Bulky disease (>10 cm) | 1.36 (1.05-1.80) | .019 | 1.38 (1.02-1.85) | .034 | 1.24 (0.95-1.62) | .110 | — | — |
| LDH > ULN | 1.49 (1.25-1.79) | <.001 | 1.40 (1.13-1.73) | .002 | 1.53 (1.28-1.83) | <.001 | 1.37 (1.11-1.69) | .003 |
| CNS | 1.70 (0.88-3.28) | .115 | — | — | 2.07 (1.11-3.87) | .023 | — | — |
| Skin | 1.29 (0.94-1.77) | .116 | — | — | 1.49 (1.10-2.02) | .011 | — | — |
| Lung | 1.36 (0.95-1.93) | .090 | — | — | 1.41 (1.00-1.99) | .049 | — | — |
| Pleural | 1.53 (1.06-2.22) | .023 | — | — | 1.58 (1.09-2.28) | .015 | — | — |
| Kidney | 2.59 (0.96-6.88) | .061 | — | — | 2.16 (0.81-5.78) | .125 | — | — |
| GI involvement | 1.64 (1.31-2.05) | <.001 | 1.65 (1.15-2.35) | .006 | 1.41 (1.13-1.77) | .002 | — | — |
| PTCL NOS | 1.00 | — | 1.00 | — | 1.00 | — | 1.00 | — |
| ALCL, ALKu | 0.98 (0.66-1.45) | .912 | 1.10 (0.71-1.70) | .678 | 0.89 (0.60-1.32) | .570 | 1.17 (0.75-1.81) | .491 |
| ALCL, ALKneg | 0.88 (0.68-1.14) | .320 | 1.03 (0.78-1.36) | .849 | 0.87 (0.68-1.12) | .276 | 1.10 (0.84-1.45) | .490 |
| ALCL, ALKpos | 0.207 (0.13-0.34) | <.001 | 0.55 (0.32-0.93) | .025 | 0.31 (0.20-0.47) | .001 | 0.66 (0.41-1.07) | .090 |
| AITL | 0.95 (0.73-1.23) | .681 | 0.78 (0.59-1.02) | .070 | 0.94 (0.73-1.22) | .650 | 0.79 (0.61-1.04) | .087 |
| EATL | 1.41 (1.05-1.90) | .022 | 1.29 (0.81-2.05) | .280 | 1.30 (0.97-1.75) | .079 | 1.96 (1.37-2.80) | <.001 |
| TCL U | 1.19 (0.86-1.64) | .296 | 1.08 (0.75-1.57) | .691 | 1.28 (0.93-1.76) | .135 | 1.15 (0.81-1.64) | .430 |
| NK/T, nt | 1.27 (0.85-1.90) | .249 | 2.18 (1.39-3.41) | .001 | 1.44 (0.96-2.17) | .079 | 2.40 (1.53-3.75) | <.001 |
| SPTCL | 0.50 (0.22-1.12) | .092 | 0.97 (0.43-2.21) | .941 | 0.67 (0.31-1.42) | .293 | 1.14 (0.53-2.46) | .733 |
| HSTCL | 1.12 (0.46-2.72) | .806 | 2.30 (0.92-5.70) | .074 | 1.20 (0.53-2.70) | .665 | 1.89 (0.82-4.35) | .136 |
| Factor . | OS (n = 685) . | PFS (n = 654) . | ||||||
|---|---|---|---|---|---|---|---|---|
| Univariable . | Multivariable . | Univariable . | Multivariable . | |||||
| . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . | HR (95% CI) . | P . |
| Age | 1.040 (1.033-1.046) | <.001 | 1.038 (1.030-1.046) | <.001 | 1.030 (1.024-1.036) | <.001 | 1.029 (1.021-1.036) | <.001 |
| Male gender | 1.16 (0.97-1.37) | .098 | 1.28 (1.06-1.55) | .011 | 1.15 (0.97-1.36) | .101 | 1.26 (1.05-1.51) | .014 |
| B symptoms | 1.65 (1.38-1.97) | <.001 | 1.31 (1.07-1.60) | .010 | 1.61 (1.35-1.92) | <.001 | 1.38 (1.13-1.69) | .002 |
| Ann Arbor III-IV | 2.00 (1.64-2.42) | <.001 | 1.41 (1.12-1.77) | .003 | 2.00 (1.65-2.42) | <.001 | 1.48 (1.18-1.85) | .003 |
| BM | 1.51 (1.24-1.85) | <.001 | — | — | 1.48 (1.22-1.79) | <.001 | — | — |
| Extranodal involvement >1 | 1.85 (1.48-2.31) | <.001 | 1.47 (1.14-1.88) | .003 | 1.81 (1.45-2.25) | <.001 | 1.55 (1.22-1.98) | <.001 |
| WHO PS >1 | 2.48 (2.09-2.94) | <.001 | 1.65 (1.34-2.02) | <.001 | 2.26 (1.91-2.68) | <.001 | 1.68 (1.37-2.04) | <.001 |
| Bulky disease (>10 cm) | 1.36 (1.05-1.80) | .019 | 1.38 (1.02-1.85) | .034 | 1.24 (0.95-1.62) | .110 | — | — |
| LDH > ULN | 1.49 (1.25-1.79) | <.001 | 1.40 (1.13-1.73) | .002 | 1.53 (1.28-1.83) | <.001 | 1.37 (1.11-1.69) | .003 |
| CNS | 1.70 (0.88-3.28) | .115 | — | — | 2.07 (1.11-3.87) | .023 | — | — |
| Skin | 1.29 (0.94-1.77) | .116 | — | — | 1.49 (1.10-2.02) | .011 | — | — |
| Lung | 1.36 (0.95-1.93) | .090 | — | — | 1.41 (1.00-1.99) | .049 | — | — |
| Pleural | 1.53 (1.06-2.22) | .023 | — | — | 1.58 (1.09-2.28) | .015 | — | — |
| Kidney | 2.59 (0.96-6.88) | .061 | — | — | 2.16 (0.81-5.78) | .125 | — | — |
| GI involvement | 1.64 (1.31-2.05) | <.001 | 1.65 (1.15-2.35) | .006 | 1.41 (1.13-1.77) | .002 | — | — |
| PTCL NOS | 1.00 | — | 1.00 | — | 1.00 | — | 1.00 | — |
| ALCL, ALKu | 0.98 (0.66-1.45) | .912 | 1.10 (0.71-1.70) | .678 | 0.89 (0.60-1.32) | .570 | 1.17 (0.75-1.81) | .491 |
| ALCL, ALKneg | 0.88 (0.68-1.14) | .320 | 1.03 (0.78-1.36) | .849 | 0.87 (0.68-1.12) | .276 | 1.10 (0.84-1.45) | .490 |
| ALCL, ALKpos | 0.207 (0.13-0.34) | <.001 | 0.55 (0.32-0.93) | .025 | 0.31 (0.20-0.47) | .001 | 0.66 (0.41-1.07) | .090 |
| AITL | 0.95 (0.73-1.23) | .681 | 0.78 (0.59-1.02) | .070 | 0.94 (0.73-1.22) | .650 | 0.79 (0.61-1.04) | .087 |
| EATL | 1.41 (1.05-1.90) | .022 | 1.29 (0.81-2.05) | .280 | 1.30 (0.97-1.75) | .079 | 1.96 (1.37-2.80) | <.001 |
| TCL U | 1.19 (0.86-1.64) | .296 | 1.08 (0.75-1.57) | .691 | 1.28 (0.93-1.76) | .135 | 1.15 (0.81-1.64) | .430 |
| NK/T, nt | 1.27 (0.85-1.90) | .249 | 2.18 (1.39-3.41) | .001 | 1.44 (0.96-2.17) | .079 | 2.40 (1.53-3.75) | <.001 |
| SPTCL | 0.50 (0.22-1.12) | .092 | 0.97 (0.43-2.21) | .941 | 0.67 (0.31-1.42) | .293 | 1.14 (0.53-2.46) | .733 |
| HSTCL | 1.12 (0.46-2.72) | .806 | 2.30 (0.92-5.70) | .074 | 1.20 (0.53-2.70) | .665 | 1.89 (0.82-4.35) | .136 |
BM, bone marrow; CNS, central nervous system; GI, gastrointestinal; LDH, lactate dehydrogenase; ULN, upper limit of normal.